227013
CCR4 Antagonist - CAS 864289-85-0 - Calbiochem
Synonym(s):
2-(1,4ʹ-Bipiperidine-1ʹ-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine, C-021
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About This Item
Assay
≥97% (HPLC)
form
solid
color
light beige
solubility
DMSO: 25 mg/mL
ethanol: 5 mg/mL
General description
A cell-permeable diaminoquinazoline compound that acts as a potent antagonist against the G-protein-coupled chemokine receptor CCR4 (IC50 = 73 and 18 nM against CCL22-binding and CCL22-induced GTPγS recruitment, respectively). Shown to inhibit CCL22/CCR4-mediated chemotaxis in both murine and human cultures (IC50 = 39 and 140 nM, respectively).
The CCR4 Antagonist controls the biological activity of CCR4. This small molecule/inhibitor is primarily used for Membrane applications.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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