Skip to Content
Merck
All Photos(1)

Key Documents

236013

Millipore

COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem

Synonym(s):

COX-2 Inhibitor III - CAS 1177728-24-3 - Calbiochem, N-(5-Acetyl-2-piperidinophenyl)-Nʹ-(2,5-dichlorophenyl)thiourea, BTB 02472

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C20H21Cl2N3OS
CAS Number:
1177728-24-3
Molecular Weight:
422.37
UNSPSC Code:
12352200

Assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

ethanol: 0.5 mg/mL
DMSO: 200 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

This product has been discontinued.



A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).

A thiourea compound that acts as an active-site-targeting COX-2 inhibitor. Exhibits better selectivity than Nimesulide and Celecoxib (% inhibition of COX-1 and COX-2 at 10.0 µM inhibitor concentration = 5.1 and 26.36 with BTB 02472; 9.87 and 19.94 with Nimesulide; 12.35 and 40.37 with Celecoxib).

Biochem/physiol Actions

Cell permeable: no
Primary Target
COX-2
Product does not compete with ATP.
Reversible: no
Target IC50: at 10.0 µM, % inhibition of COX-1 and COX-2 = 5.1 and 26.36

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Michaux, C., et al. 2006. Eur. J. Med. Chem.41, 1446.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service