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Key Documents

COA/COQ

323115

DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem

Name: DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem
Brand: MM

Synonym(s):

DNA Repair Pathway Inhibitor, NS-123 - CAS 101860-83-7 - Calbiochem, 4ʹ-Bromo-3ʹ-nitropropiophenone, Radiation Sensitizer, NS-123

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About This Item

Empirical Formula (Hill Notation):

C₉H₈BrNO₃

CAS Number:

101860-83-7

Molecular Weight:

258.07

UNSPSC Code:

12352200

Assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C9H8BrNO3/c1-2-9(12)6-3-4-7(10)8(5-6)11(13)14/h3-5H,2H2,1H3

InChI key

TZELZSUMAATQRO-UHFFFAOYSA-N

General description

A cell-permeable nitro-propiophenone compound that preferentially enhances tumor growth-inhibitory effects of ionizing radiation (~ 5 µM in U251, HT-29 and A549 tumor cells and in U251 xenograft mouse model, 50 mg/kg, i.p.) with no apparent effect on normal human glial cells, Zebrafish embryos and nude mice. Shown to increase the accumulation of unrepaired double-strand DNA breaks and prolong the damage-dependent signaling.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Lally, B.E., et al. 2007. Cancer Res.67, 8791.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

10-13 - German Storage Class 10 to 13

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