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324510

Sigma-Aldrich

EF24 - Calbiochem

Synonym(s):

EF24 - Calbiochem, 3,5- bis-(2-Fluorobenzylidene)-piperidin-4-one, Curcumin Analog, EF24, IKK Inhibitor XIV, 3,5-bis-(2-Fluorobenzylidene)-piperidin-4-one, Curcumin Analog, EF24, IKK Inhibitor XIV

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About This Item

Empirical Formula (Hill Notation):
C19H15F2NO
Molecular Weight:
311.33
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 15 mg/mL
ethanol: 4 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

This product has been discontinued.



A cell-permeable Curcumin (Cat. No. 239802) structural analog that is shown to be at least 10-fold more potent than Curcumin as an IKKβ inhibitor (IC50 = 1.9 µM) and in blocking TNFα-induced cellular I-κB phosphorylation (IC50 = 5.7 µM) and NF-κB nuclear translocation (IC50 = 1.3 µM), as well as in its anticancer activity (IC50 ranges from 0.44 to 2.07 µM) in vitro. Reported to completely stop the expansion of HCT-116-derived tumor in mice (200 µg/kg daily i.p.) in vivo.

A cell-permeable Curcumin (Cat. No. 239802) structural analog that is shown to be at least 10-fold more potent than Curcumin as an IKKβ inhibitor (IC50 = 1.9 vs. 20 µM, respectively) and in blocking TNFα-induced cellular I-κB phosphorylation (IC50 = 5.7 vs. >50 µM, respectively) and NF-κB nuclear translocation (IC50 = 1.3 vs. 13 µM, respectively) in A549 cultures, as well as in its anticancer activity (EC50 ranges from 0.44 to 2.07 µM against various cancer cell lines). Reported to completely stop the continued volume expansion of 1-week-old HCT-116-derived tumor in mice (200 µg/kg daily i.p.) in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. When stored at room temperature in DMSO, 2.5% decomposition per day is expected.

Other Notes

Subramaniam, D., et al. 2008. Cancer Res.68, 1962.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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