Key Documents
324631
Eg5 Inhibitor VII - CAS 912953-25-4 - Calbiochem
Synonym(s):
KSP Inhibitor VII; 6-(4-Trifluoromethyl)phenyl)-3,4-dihydro-2(1H)-quinolinone, GSK-1
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About This Item
Assay
≥97% (HPLC)
form
powder
color
off-white
solubility
DMSO: 10 mg/mL
General description
A cell-permeable quinolinone compound that acts as a highly potent and selective Eg5/KSP inhibitor (Ki = 1.4, 2.1, 2.2, and 1.7 nM for the mutant A133D, KHC-L5, D130V, and the wild-type KSP, respectively) by antagonizing ATP binding via an allosteric site. Effectively induces monopolar spindles in ovarian adenocarcinoma SKOV3 cells and inhibits the proliferation of colorectal carcinoma HCT116 cells (IC50 = 36 and 0.5 nM againt the parental and the ispinesib-resistant D130V mutant line, respectively). It is uncompetitive with respect to microtubule and exhibits little activity against a panel of 7 other mitotic kinesins.
The Eg5 Inhibitor VII controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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