344960
FUT-175 - CAS 82956-11-4 - Calbiochem
Synonym(s):
Futhan, 6-Amidino-2-naphthyl-4-guanidinobenzoate Dimethanesulfonate, Nafamostat Mesylate
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About This Item
Assay
≥98% (HPLC)
form
solid
color
off-white
solubility
H2O: 5 mg/mL
General description
A synthetic broad-specificity serine protease inhibitor. Potently inhibits both coagulation and complement proteinases (C3a, C4a, and C5a) as well as Granzyme A. Inhibits Factor VIIa-mediated, Factor Xa generation (IC50 = 100 nM). Also effective toward Hageman factor at submicromolar concentrations.
Biochem/physiol Actions
Granzyme A
Preparation Note
Following reconstitution aliquot and freeze (-80°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions in H₂O are stable for up to 6 months at -80°C or up to 4 weeks at 4°C.
Disclaimer
The use of PBS or other phosphate-containing buffers should be avoided as it may reduce solubility.
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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