Key Documents
345883
GGTI-298 - CAS 180977-44-0 - Calbiochem
Synonym(s):
N-4-[2(R)-Amino-3-mercaptopropyl]amino-2-naphthylbenzoyl-(L)-Leucine methyl ester, TFA
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About This Item
General description
A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297 (Cat. No. 345882). Inhibits the processing of Rap 1A (IC50 = 3 μM) but had no effect on the processing of H-Ras even at concentrations of 15 μM. Also arrests cells in the G0/G1 phase of the cell cycle, induces apoptosis and enhances nitric oxide synthase-2 induction by IL-1β.
A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297 (Cat. No. 345882). Inhibits the processing of Rap 1A (IC50 = 3 μM) but has no effect on the processing of H-Ras even at concentrations of 15 μM. Inhibits PDGF-receptor tyrosine phosphorylation. Also arrests cells in the G0/G1 phase of the cell cycle, induces apoptosis, and enhances iNOS induction by IL-1β.
A cell-permeable, prodrug form of the GGTase I inhibitor GGTI-297.
Biochem/physiol Actions
Target IC50:3 μM against processing of Rap 1A
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Degas DMSO just prior to reconstitution
Following reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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