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346110

Sigma-Aldrich

Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem

A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor ligand with a binding affinity that is 4-fold higher than that of Dexamethasone.

Synonym(s):

Glucocorticoid Receptor Modulator, CpdA - CAS 14593-25-0 - Calbiochem, 2-((4-Acetoxyphenyl)-2-chloro-N-methyl)ethylammonium chloride

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About This Item

Empirical Formula (Hill Notation):
C11H14ClNO2 · xHCl
CAS Number:
14593-25-0
Molecular Weight:
227.69 (free base basis)
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

color

white

solubility

water: 1 mg/mL
DMSO: 10 mg/mL
anhydrous ethanol: 5 mg/mL

shipped in

wet ice

storage temp.

−70°C

General description

This product has been discontinued.



A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand with a binding affinity that is 4-fold higher than that of Dexamethasone (DEX, Cat. No. 265005). Induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression. Reported to be as effective as DEX in suppressing acute inflammation in mice in vivo without the hyperglycemic side effect that is commonly associated with DEX.

A cell-permeable aziridine precursor that acts as a nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand with a binding affinity that is 4-fold higher than that of Dexamethasone (DEX, Cat. No. 265005). Induces GR nuclear translocation and selectively activates GR-mediated transrepression of the NF-κB-dependent production of pro-inflammatory cytokines. Unlike DEX, CpdA exhibits no effect on GRE- (glucocorticoid response element) driven gene expression. Reported to be as effective as DEX in suppressing acute inflammation in mice in vivo without the hyperglycemic side effect that is commonly associated with DEX.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
A nonsteroidal glucocorticoid receptor (GR, Cat. No. 346100) ligand
Product does not compete with ATP.
Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-70°C). Ethanol stock solutions are stable for up to 1 month at -70°C.

Other Notes

De Bosscher, K., et al. 2005. Proc. Natl. Acad. Sci. USA102, 15827.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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