373225
Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem
The Hdm2 E3 Ligase Inhibitor, also referenced under CAS 414905-09-2, controls the biological activity of Hdm2 E3 Ligase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
Hdm2 E3 Ligase Inhibitor - CAS 414905-09-2 - Calbiochem, N-((3,3,3-Trifluoro-2-trifluromethyl)propionyl)sulfanilamide, Mdm2 E3 Ligase Inhibitor, MDM2 Inhibitor V
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About This Item
Empirical Formula (Hill Notation):
C10H8F6N2O3S
CAS Number:
Molecular Weight:
350.24
UNSPSC Code:
12352200
Quality Level
Assay
≥95% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
pale yellow
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable and reversible inhibitor of Hdm2 E3 ligase that selectively blocks Hdm2 E3-mediated ubiquitination. Has been shown to inhibit ubiquitination of p53 in vitro (IC50 = 12.7 µM using Ub-Ubc as the donor substrate). Exhibits little effect towards other ubiquitin-using enzymes (IC50 >100 µM for E1, Nedd-4, and SCF) or the auto-ubiquitination activity of Hdm2. The inhibition is non-competitive with respect to either the donor or acceptor substrate.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
ubiquitination of p53 in vitro
ubiquitination of p53 in vitro
Product does not compete with ATP.
Reversible: yes
Target IC50: 12.7 µM inhibiting ubiquitination of p53 in vitro using Ub-Ubc as the donor substrate
Packaging
Packaged under inert gas
Other Notes
Lai, Z., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14734.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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