402081
Indirubin Derivative E804 - CAS 854171-35-0 - Calbiochem
Synonym(s):
Indirubin Derivative E804 - CAS 854171-35-0 - Calbiochem, IDR E804
About This Item
Assay
≥95% (HPLC)
Quality Level
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
dark red
solubility
DMSO: 200 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
This product has been discontinued.
A cell-permeable indirubin derivative (IDR) that blocks the Src-Stat3 signaling pathway and displays anti-tumor properties. Shown to be a potent, reversible, and ATP-competitive inhibitor of the kinase activities of Src (IC50 = 430 nM), Cdk1/cyclin E (IC50 = 210 nM), Cdk2/cyclin A (IC50 = 540 nM), and Cdk1/cyclin B (IC50 = 1.65 µM). Reduces the tyrosine phosphorylation levels of Src, JAK1, and Stat3 in MDA-MB-468 cells in a time- and dose-dependent manner. Selectively induces apoptosis in cells expressing high levels of active Stat3, but not cells lacking activated Stat3. The apoptotic effect of E804 is shown to be due to the down-regulation of antiapoptotic proteins Mcl-1 and survivin.
Biochem/physiol Actions
Src
Packaging
Preparation Note
Other Notes
Legal Information
Disclaimer
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
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