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402086

Millipore

Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem

Synonym(s):

Indirubin-3ʹ-monoxime, 5-Iodo- - CAS 331467-03-9 - Calbiochem

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About This Item

Empirical Formula (Hill Notation):
C16H10IN3O2
CAS Number:
331467-03-9
Molecular Weight:
403.17
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

dark red

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

This product has been discontinued.



A highly potent cell-permeable and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50 = 9 nM). Also inhibits Cdk1 (IC50 = 25 nM) and Cdk5 (IC50 = 20 nM) activities. Acts by binding to the ATP-binding pocket of these enzymes.

A highly potent, cell-permeable, and reversible inhibitor of glycogen synthase kinase-3β (GSK-3β) (IC50 = 9 nM). Reported to inhibit GSK-3β phosphorylation of human tau protein in vitro (IC50 ~100 nM) and in cells (effective concentration = 20 µM). Also inhibits CDK1 (IC50 = 25 nM) and CDK5 (IC50 = 20 nM). Shown to inhibit phosphorylation of DARPP-32 by CDK5 in brain sections enriched for DARPP-32. Inhibition is competitive with respect to ATP.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Gsk-3β
Product competes with ATP.
Reversible: yes
Target IC50: 9 nM against GSK-3β

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Leclerc, S., et al. 2001. J. Biol. Chem.276, 251.
Hoessel, R., et al. 1999. Nat. Cell Biol.1, 60.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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