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Key Documents

407271

Sigma-Aldrich

Integrin αMβ₂ Ligand - CAS 307525-40-2 - Calbiochem

Synonym(s):

Integrin αMβ₂ Ligand - CAS 307525-40-2 - Calbiochem, 3-(o-Tolyl)-5-(3-phenyl-2-propenylidene)-2-thioxo-1,3-thiazolin-4-one, IMB-10, CD11b Agonist I, CD11b/CD18 Agonist I, CR3 Agonist I, Mac-1 Agonist I, αMβ2 Agonist I

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About This Item

Empirical Formula (Hill Notation):
C19H15NOS2
CAS Number:
307525-40-2
Molecular Weight:
337.46
MDL number:
MFCD20134199
UNSPSC Code:
12352200

Assay

≥98% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 15 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable thioxothiazolidine compound that displays anti-inflammatory properties. Shown to increase cell adhesion and lowers leukemia cell migration in vitro and leukocyte recruitment in vivo and displays anti-inflammatory properties. Binds to and stabilizes integrin αM I domain active conformation and enhances the ligands′ (pro-MMP-9 and fibrinogen) binding ability.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Binds to and stabilizes integrin αM I domain active conformation
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Other Notes

Bjorklund, M., et al. 2006. Biochemistry45, 2862.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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