407314
Anti-Integrin β₃ (Ab-1) Mouse mAb (290.5C10)
Synonym(s):
Anti-CD61
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About This Item
antibody form
ascites fluid
Quality Level
clone
290.5C10, monoclonal
form
liquid
species reactivity
human
isotype
IgG1
General description
Mouse monoclonal antibody supplied as undiluted ascites. Recognizes the β3 integrin subunit in αvβ3 and αllbβ3 integrin protein complexes.
Recognizes the β3 integrin subunit in αvβ3 and αllbβ3 integrin protein complexes.
The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated α and β subunits. CD61 non-covalently associates with CD41 (αIlb integrin) and is expressed by megakaryocytes and platelets. The CD61/CD41 complex acts as a receptor for such adhesive ligands as fibronectin, fibrinogen and von Willebrand factor during platelet stimulation.
Immunogen
β₃ integrin from M21 melanoma cells
Application
ELISA (see comments)
Flow Cytometry (1:50-1:100)
Immunoblotting (1:50-1:100)
Paraffin Sections (1:50-1:100)
Immunoprecipitation (1:50-1:100)
Flow Cytometry (1:50-1:100)
Immunoblotting (1:50-1:100)
Paraffin Sections (1:50-1:100)
Immunoprecipitation (1:50-1:100)
Physical form
Undiluted ascites.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
This antibody has also been reported to work for ELISA. Variables associated with assay conditions will dictate the proper working dilution.
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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