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5.04479

JNJ 16259685 - CAS 409345-29-5 - Calbiochem

Synonym(s):

JNJ 16259685 - CAS 409345-29-5 - Calbiochem, (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone

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About This Item

Empirical Formula (Hill Notation):
C20H23NO3
CAS Number:
409345-29-5
Molecular Weight:
325.40
UNSPSC Code:
12352200
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assay

≥98% (TLC)

Quality Segment

100

form

solid

potency

0.55 nM IC50, 0.34 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

white to off-white

solubility

DMSO: 25 mM

storage temp.

2-8°C

General description

An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (Ki = 0.34 nM; IC50 = 0.55 nM). 400-fold more selective for mGlu1 than for mGlu5 and no interaction with mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.

Biochem/physiol Actions

Primary Target
mGlu₁

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lavreysen, H., et al. 2004. Neuropharmacology.47, 961.

Steckler, T., et al. 2005. Psychopharmacology.179, 198.

Steckler, T., et al. 2005. Behav. Brain. Res.164, 52.

Mabire, D., et al. 2005. J. Med. Chem.48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol.151, 870.

Knopfel, T., et al. 2007. Br. J. Pharmacol.151, 723.

Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther.343, 214.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

5044790002: + 5044790001:

jan

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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