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5.05311

Sigma-Aldrich

Gallamine Triethiodide - CAS 65-29-2 - Calbiochem

Synonym(s):

Gallamine Triethiodide - CAS 65-29-2 - Calbiochem, 2,2ʹ,2ʹʹ-(benzene-1,2,3-triyltris(oxy))tris(N,N,N-triethylethanaminium) iodide, Muscarinic Receptor Antagonist, Gallamine Triethiodide, Muscarinic mAChR Antagonist, Gallamine Triethiodide

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About This Item

Empirical Formula (Hill Notation):
C30H60I3N3O3
CAS Number:
65-29-2
Molecular Weight:
891.53
MDL number:
MFCD00011832
UNSPSC Code:
12352200

Assay

≥98% (TLC)

Quality Level

100

form

powder

potency

2.4 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

water: 100 mg/mL

storage temp.

2-8°C

InChI

1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3

InChI key

REEUVFCVXKWOFE-UHFFFAOYSA-K

General description

A negative allosteric modulator selective for muscarinic AChRs. Most selective for M2 receptors (Ki = 2.4 nM) over other mAChRs (M2 > M1 = M4 > M3 = M5). Used to study the roles of M2 receptors in neuromuscular transmission and neuroimmunology.

Biochem/physiol Actions

Primary Target
mAChR
Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Beltrame, P., 2011. Clin. Exp. Immunol.164, 170.
Gnagey, A., et al., 1999. Mol. Pharmacol.56, 1245.
Leppik, A., et al. 1994. Mol. Pharmacol.45, 983.
Burke, E., 1986. Mol. Pharmacol.30, 58.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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