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Key Documents

COA/COQ

5.09706

DFB

Name: DFB
Brand: MM

Synonym(s):

DFB, [(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde, 3,3ʹ-Difluorobenzaldazine

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₀F₂N₂

CAS Number:

15332-10-2

Molecular Weight:

244.24

MDL number:

MFCD03653615

UNSPSC Code:

12352200

Assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 12 mg/mL

storage temp.

2-8°C

InChI

1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9-,18-10-

InChI key

YYMCVDNIIFNDJK-XFQWXJFMSA-N

General description

A positive allosteric modulator for mGlu receptor subtype 5 (EC₅₀ = 2 - 5.3 µM). No agonistic action on mGlu₅. Renders 3-6 fold potentiation for Glu5 agonists. No effect on other mGlu receptor subtypes.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
mGlu₅

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

OʹBrien, J., et al. 2003. Mol. Pharmacol.64, 731.
Zhang Z., et al. 2005. J. Pharmacol. Exp. Ther.315, 1212.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Pictograms

GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302 - H400

Precautionary Statements

P264 - P270 - P273 - P301 + P312 - P391 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)