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521232

Sigma-Aldrich

PDGFR Tyrosine Kinase Inhibitor III - CAS 205254-94-0 - Calbiochem

Synonym(s):

4-(6,7-Dimethoxy-4-quinazolinyl)-N-(4-phenoxyphenyl)-1-piperazinecarboxamide

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About This Item

UNSPSC Code:
12352200

Assay

≥97% (HPLC)

Quality Level

form

solid

color

white

solubility

DMSO: 10 mg/mL

General description

A cell-permeable piperazinyl-quinazoline carboxamide compound that acts as a potent, ATP-competitive, reversible, and selective inhibitor of PDGF receptor family of tyrosine kinases (IC50 = 0.05 μM for α-PDGFR; 0.08 μM for β-PDGFR; 0.05 μM for c-Kit; 0.23 μM for Flt3). Affects the activities of other kinases only at much higher concentrations (IC50 ≥ 30 μM for EGFR, FGFR, Src, PKA & PKC). Reported to block the PDGF-BB induced proliferation of porcine aorta smooth muscle cells (IC50 = 0.25 μM).

Biochem/physiol Actions

Target IC50:0.05 μM for α-PDGFR; 0.08 μM for β-PDGFR; 0.05 μM for c-Kit; 0.23 μM for Flt3

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Storage Class Code

10-13 - German Storage Class 10 to 13


Certificates of Analysis (COA)

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