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521236

Sigma-Aldrich

PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem

The PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 controls the biological activity of PDGFR/VEGFR2 Tyrosine Kinase. Primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

PDGFR/VEGFR2 Tyrosine Kinase Inhibitor, 5-Br SU6668 - CAS 251356-32-8 - Calbiochem, (Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid, PDGFR Tyrosine Kinase Inhibitor XV, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XXVI, PDGFR Tyrosine Kinase Inhibitor XV, (Z)-3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl-5-bromo)-1H-pyrrol-3-yl)-propionic acid, VEGFR Tyrosine Kinase Inhibitor XXIII, VEGFR2 Kinase Inhibitor XXVI

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About This Item

Empirical Formula (Hill Notation):
C18H17BrN2O3
CAS Number:
251356-32-8
Molecular Weight:
389.24
UNSPSC Code:
12352200

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

orange

solubility

DMSO: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

This product has been discontinued.



A cell-permeable, ATP-binding pocket-targeting, 5-bromoindolinone analog of SU6668 (Cat. No. 521235) that is equally potent as SU6668 in inhibiting PDGFR (IC50 = 60 nM against PDGFRβ), while exhibiting more enhanced activity against VEGFR2 and FGFR1 (IC50 = 1.73 and 2.05 µM, respectively) in cell-free kinase assays. Inhibits cell proliferation mediated by VEGF, FGF, and PDGFβ, but is of little effect against EGF-mediated cell proliferation or EGFR in vitro kinase activity.

A cell-permeable, ATP-binding pocket-targeting, 5-bromoindolinone analog of SU6668 (Cat. No. 521235) that is equally potent as SU6668 in inhibiting PDGFR (IC50 = 60 nM against PDGFRβ), while exhibiting more enhanced activity against VEGFR2 and FGFR1 (IC50 = 1.73 and 2.05 µM, respectively) in cell-free kinase assays. Inhibits cell proliferation mediated by VEGF, FGF, and PDGFβ, but is of little effect against EGF-mediated cell proliferation or EGFR in vitro kinase activity.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Sun, L. et al. 1999. J. Med. Chem.42, 5120.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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