526522
PIM1 Kinase Inhibitor IV
The PIM1 Kinase Inhibitor IV, also referenced under CAS 477845-12-8, controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
PIM1 Kinase Inhibitor IV, 4-(3-(4-Chlorophenyl)-2,1-benzisoxazol-5-yl)-2-pyrimidinamine
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About This Item
Empirical Formula (Hill Notation):
C17H11ClN4O
CAS Number:
Molecular Weight:
322.75
UNSPSC Code:
12352200
Quality Level
Assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellow
solubility
DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A pyrimidinyl-benzisoxazolo compound that interacts with Lys67 and Glu121 at the PIM1 active site and inhibits PIM1 kinase activity with a Ki value of 0.091 µM.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Pierce, A.C., et al. 2008. J. Med. Chem.51, 1972.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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