5.31294
Perk Inhibitor III, LDN-0070977
Synonym(s):
Perk Inhibitor III, LDN-0070977, LDN 0070977, PKR-like ER kinase Inhibitor, LDN-0070977, LDN0070977
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About This Item
Empirical Formula (Hill Notation):
C12H8N2O
CAS Number:
Molecular Weight:
196.20
MDL number:
UNSPSC Code:
12352200
Assay
≥98% (HPLC)
Quality Level
form
powder
potency
7 μM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
SMILES string
O/N=C(C1=C2N=CC=C1)/C3=C2C=CC=C3
General description
A cell-permeable tricyclic heterocycle oxime that acts as a reversible and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC50 = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a. Shown to reduce thapsigargin-induced elF2a phosphorylation in mouse embryonic fibroblasts over a wide range. Does not exhibit any cellular toxicity up to 50 µM levels.
A cell-permeable, reversible, and non ATP-competitive inhibitor of PERK (PKR-like ER kinase, IC₅₀ = 7.04 µM) and blocks PERK-dependent phosphorylation of elF2a.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PERK
PERK
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Pytel, D., et al. 2014. J. Biomol. Screen.19, 1024.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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