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540210

Sigma-Aldrich

PTP Inhibitor III - CAS 29936-81-0 - Calbiochem

Synonym(s):

PTP Inhibitor III - CAS 29936-81-0 - Calbiochem, α-Bromo-4-(carboxymethoxy)acetophenone, 4-(Carboxymethoxy)phenacyl Br, Protein Tyrosine Phosphatase Inhibitor III, SHP1 Inhibitor III, PTP-MEG2/PTPN9 Inhibitor, PTP-β Inhibitor, PTP-δ Inhibitor, PTP-ε Inhibitor, PTP-µ Inhibitor,

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About This Item

Empirical Formula (Hill Notation):
C10H9BrO4
CAS Number:
29936-81-0
Molecular Weight:
273.08
UNSPSC Code:
12352200

Assay

≥90% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

white

solubility

DMSO: 200 mg/mL

shipped in

wet ice

storage temp.

−70°C

General description

A potent, cell-permeable, and covalent Protein Tyrosine Phosphatase (PTP) inhibitor. Binds to SHP-1(ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1, with lower affinity that PTP Inhibitor I (Cat. No. 540200) (Ki = 193 µM versus Ki = 43 mM) but with a higher kinact (1.8 min-1 versus 0.40 min-1). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
protein tyrosine phosphatase (PTP)
Product does not compete with ATP.
Reversible: yes
Target IC50: 193 µM against PTP

Packaging

Packaged under inert gas

Preparation Note

Unstable in DMSO; reconstitute just prior to use. Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Arabaci, G., et al. 1999. J. Am. Chem. Soc.121, 5085.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Corrosive (L)

Storage Class Code

8A - Combustible corrosive hazardous materials

Certificates of Analysis (COA)

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