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Key Documents

COA/COQ

557362

Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem

Name: Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem
Brand: MM

Synonym(s):

Roscovitine, (S)-Isomer - CAS 186692-45-5 - Calbiochem, 2-(S)-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine, Cdk7 Inhibitor I, (S)-Isomer

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₆N₆O

CAS Number:

186692-45-5

Molecular Weight:

354.45

UNSPSC Code:

12352200

Assay

≥95% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

white

solubility

DMSO: 100 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

This product has been discontinued.

The (S)-enantiomer of the potent cyclin-dependent kinase (Cdk) inhibitor Roscovitine (Cat. No. 557360). Potently inhibits p34^cdk1/cyclin B kinase (IC₅₀ = 800 nM).

The (S)-enantiomer of the potent cyclin-dependent kinase (cdk) inhibitor Roscovitine (Cat. No. 557360). Potently inhibits p34^cdc2/cyclin B kinase (IC₅₀ = 800 nM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
p34^cdk1/cyclin B kinase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 800 nM against p34cdk1/cyclin B kinase

Other Notes

Havlicek, L., et al. 1997. J. Med. Chem. 40, 408.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

10-13 - German Storage Class 10 to 13

Certificates of Analysis (COA)

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