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Merck

567051-M

Sinefungin

InSolution, ≥95%, antibiotic

Synonym(s):

InSolution Sinefungin, SF, Adenosyl-ornithine, A9145

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About This Item

Empirical Formula (Hill Notation):
C15H23N7O5
CAS Number:
Molecular Weight:
381.39
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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SMILES string

[n]2(c3ncnc(c3nc2)N)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C[C@@H](N)CC[C@H](N)C(=O)O

InChI

1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1

InChI key

LMXOHSDXUQEUSF-YECHIGJVSA-N

assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

storage temp.

−20°C

Quality Level

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General description

An anti-leishmanial nucleoside antibiotic that acts as an S-adenosyl-L-methionine (SAM, AdoMet) methyltransferase-specific inhibitor.

Biochem/physiol Actions

Primary Target
S-adenosyl-L-methionine (SAM, AdoMet) methyltransferase

Physical form

A 10 mM (2 mg/524 µl) solution in H₂O.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Lin, Q., et al. 2001. J. Am. Chem. Soc.123, 11608.
Zingg, J.M., et al. 1996. Nucleic Acids Res.24, 3267.
McCammon, M.T., and Parks, L.W. 1981. J. Bacteriol.145, 106.
Pugh, C.S.G., et al. 1978. J. Biol. Chem.253, 4075.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3


Certificates of Analysis (COA)

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