Stromal Cell-Derived Factor 1α, Human, Recombinant, E. coli

Recombinant, human SDF-1α (amino acids 22-89) expressed in E. coli. Chemoattractant for T lymphocytes and monocytes. A member of the CXC family that binds to the CXCR4 receptor and has been shown to be a potent inhibitor of infection by lymphocyte-tropic HIV-1 strains. Attracts mature lymphocytes to the bone marrow and may be involved in graft rejection.

Recombinant, human SDF-1α (amino acids 22-89) expressed in E. coli. Chemoattractant for T-lymphocytes and monocytes. Binds to the CXCR4 receptor and has been shown to be a potent inhibitor of infection by lymphocyte-tropic HIV-1 strains.

ED₅₀ = 3-9 ng/ml as measured by its ability to chemoattract 5-10 day cultured human T lymphocytes

Lyophilized from a sterile-filtered solution of 30% acetonitrile, 0.1% TFA, 50 µg BSA/µg rhSDF-1α.

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.

Reconstitute to a concentration ≥10 µg/ml with sterile PBS, ≥0.1% HSA or BSA.

Elisseeva, E.L., et al. 2000. J. Biol. Chem. 275, 26799.
Bleul, C., et al. 1996. Nature 382, 829.
Oberlin, E., et al. 1996. Nature382, 833.
Tashiro, K., et al. 1993. Science261, 600.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)