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676480

Sigma-Aldrich

VEGFR2 Kinase Inhibitor I - CAS 15966-93-5 - Calbiochem

The VEGFR2 Kinase Inhibitor I, also referenced under CAS 15966-93-5, controls the biological activity of VEGFR2 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

VEGFR2 Kinase Inhibitor I - CAS 15966-93-5 - Calbiochem, ( Z)-3-[(2,4-Dimethyl-3-(ethoxycarbonyl)pyrrol-5-yl)methylidenyl]indolin-2-one, VEGF Receptor 2 Kinase Inhibitor I, VEGFR Tyrosine Kinase Inhibitor XII

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About This Item

Empirical Formula (Hill Notation):
C18H18N2O3
CAS Number:
15966-93-5
Molecular Weight:
310.35
UNSPSC Code:
12352200

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

ethanol: 1 mg/mL
DMSO: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

A highly selective, cell-permeable, reversible, and ATP-competitive indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. Does not inhibit PDGF, EGF, and IGF-1 RTK activities (IC50 >100 µM).
A highly selective, cell-permeable, reversible, and ATP-competitive indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nm) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. It does not inhibit PDGFR, EGFR, and IGF-1 tyrosine kinase activities (IC50 >100 µm).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
(RTK) inhibitor
Product competes with ATP.
Reversible: yes
Target IC50: 70 nM against receptor tyrosine kinase (RTK)

Packaging

Packaged under inert gas

Other Notes

Sun, L., et al. 1998. J. Med. Chem.41, 2588.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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