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676501

Sigma-Aldrich

VEGFR Tyrosine Kinase Inhibitor V - Calbiochem

The VEGFR Tyrosine Kinase Inhibitor V controls the biological activity of VEGFR Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

VEGFR Tyrosine Kinase Inhibitor V - Calbiochem, N-Cyclopropyl-6-(6,7-dimethoxyquinolin-4-yloxy)-1-naphthamide, HCl, VEGF Receptor Tyrosine Kinase Inhibitor V, VEGFR2 Kinase Inhibitor XXIII, VEGFR1 Kinase Inhibitor VI, VEGFR3 Kinase Inhibitor VI

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About This Item

Empirical Formula (Hill Notation):
C25H22N2O4 · xHCl · yH2O
Molecular Weight:
414.45 (anhydrous free base basis)
UNSPSC Code:
12352200

Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

beige

solubility

ethanol: 0.2 mg/mL
DMSO: 0.5 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable, ATP-binding pocket-targeting N-cyclopropylnaphthamide compound that acts as a potent inhibitor against VEGFR1/2/3 (IC50 = 0.6 nM against VEGFR2), c-FMS, RET, Lyn, and c-KIt, while exhibiting much reduced activity against 36 other commonly studied kinases. Selectively inhibits HUVEC proliferation induced by VEGF over bFGF (IC50 = 0.91 vs. 170 nM, respectively). It is orally active in mice and rats and is shown to effectively reduce VEGF-mediated vascular permeability and angiogenesis in vivo.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Harmange, J.C., et al. 2008. J. Med. Chem.51, 1649.
Weiss, M.M., et al. 2008. J. Med. Chem.51, 1668.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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