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Merck

869001-M

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.

Synonym(s):

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, Follitropin, hFSH

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About This Item

CAS Number:
9002-68-0
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00131099
biological source:
human pituitary glands
form:
lyophilized solid
assay:
≥90%

Product Name

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.

biological source

human pituitary glands

description

Merck USA index - 14, 4223

sterility

non-sterile

product line

Calbiochem®

assay

≥90%

form

lyophilized solid

specific activity

≥2000 IU/mg

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

≤0.1% hCG
≤0.5% hLH, hTSH

pI 

4.1

solubility

PBS: soluble

storage temp.

−20°C

Quality Level

200

Related Categories

Biochem/physiol Actions

Follicle-stimulating hormone (FSH) participates in the regulation of reproduction in mammals. It exerts its effects through a G-protein-coupled receptor known as follicle-stimulating hormone receptor (FSHR) that is located on the granulosa cells of the ovaries and Sertoli cells of the testes. FSH plays a role in the maturation of ovarian follicles in females and supports spermatogenesis by activating Sertoli cell proliferation in males. The interaction of FSH with its receptor FSH-R leads to the activation of G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to transmit intracellular signals.

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

General description

Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones. It is synthesized in the gonadotrophs present in the pituitary gland. FSH contains non-covalently associated α- and β-subunits and is a disulfide-rich heterodimer.

Research area: Cell Signaling

Other Notes

Costrici, N., et al. 1995. Endocrinology136, 4705.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T R Kumar et al.
Nature genetics, 15(2), 201-204 (1997-02-01)
Follicle stimulating hormone (FSH) is a member of the glycoprotein hormone family that includes luteinzing hormone (LH), thyroid stimulating hormone, and chorionic gonadotropin. These heterodimeric hormones share a common alpha subunit and differ in their hormone-specific beta subunit. The biological
Qing R Fan et al.
Nature, 433(7023), 269-277 (2005-01-22)
Follicle-stimulating hormone (FSH) is central to reproduction in mammals. It acts through a G-protein-coupled receptor on the surface of target cells to stimulate testicular and ovarian functions. We present here the 2.9-A-resolution structure of a partially deglycosylated complex of human
Alfredo Ulloa-Aguirre et al.
Endocrinology, 159(8), 3020-3035 (2018-07-10)
FSH is synthesized in the pituitary by gonadotrope cells. By binding to and interacting with its cognate receptor [FSH receptor (FSHR)] in the gonads, this gonadotropin plays a key role in the control of gonadal function and reproduction. Upon activation

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