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Merck

CX1058

Chloroform

HPLC, Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs

Synonym(s):

Trichloromethane, Methylidyne trichloride

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About This Item

Empirical Formula (Hill Notation):
CHCl3
CAS Number:
67-66-3
Molecular Weight:
119.38
EC Index Number:
200-663-8
UNSPSC Code:
12352101
Beilstein/REAXYS Number:
1731042
MDL number:
MFCD00000826
assay:
≥99.8% chloroform + ethanol basis
technique(s):
HPLC: suitable
bp:
60.5-61.5 °C (lit.)
vapor pressure:
160 mmHg ( 20 °C)

Product Name

Chloroform, HPLC, Meets ACS Specifications, Meets Reagent Specifications for testing USP/NF monographs

SMILES string

ClC(Cl)Cl

InChI

1S/CHCl3/c2-1(3)4/h1H

InChI key

HEDRZPFGACZZDS-UHFFFAOYSA-N

agency

meets USP/NF

vapor density

4.1 (vs air)

vapor pressure

160 mmHg ( 20 °C)

assay

≥99.8% chloroform + ethanol basis

form

liquid

contains

0.5-1.9 % (v/v) ethanol as stabilizer

technique(s)

HPLC: suitable

impurities

≤0.01% Water (H2O)
≤0.05 ppm Lead (Pb)

evapn. residue

≤2 ppm

color

APHA: ≤10

refractive index

n20/D 1.445 (lit.)

bp

60.5-61.5 °C (lit.)

mp

−63 °C (lit.)

solubility

8.7 g/L

density

1.492 g/mL at 25 °C (lit.)

UV cutoff

≤245 nm

UV absorption

λ: 245 nm Amax: ≤1.00
λ: 255 nm Amax: ≤0.25
λ: 260 nm Amax: ≤0.15
λ: 270 nm Amax: ≤0.05
λ: 290-400 nm Amax: ≤0.01

shipped in

ambient

storage temp.

room temp

Quality Level

100

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Analysis Note

Acetone and Aldehydes (about 0.005%)To pass testAcid and chlorideTo pass testAppearanceClear liquid, free from particulatesAssay (CHCl3 + C2H5OH)99.8% minColor (APHA)10 maxDensity at 25°C1.465-1.476g/mlEthanol0.5-1.9% (v/v)Evaporation residue2ppm maxFiltered through 0.2 µm filterTo pass testFluorescence (as quinine base)1.0ppb maxFree chlorine (Cl)To pass testInfrared SpectrumConforms to standardLead (Pb)0.05ppm maxSubstances darkened by sulfuric acidTo pass testSuitability for determination with dithizoneTo pass testUV Abs. at 245 nm1.00AU maxUV Abs. at 255 nm0.25AU maxUV Abs. at 260 nm0.15AU maxUV Abs. at 270 nm0.05AU maxUV Abs. at 290 - 400 nm0.01AU maxUV Cut-off245nm maxWater (H2O)0.01% max

Application

CX1058P-1 is packaged in poly coated glass bottles
Meets ACS Specifications.Stabilized with 0.75% ethanol.
Chloroform can be used as a:
  • Solvent for the extraction of organic analytes from mixtures, enhancing the efficiency of separation processes.
  • Mobile phase in reverse phase high-performance liquid chromatography (RP-HPLC) to facilitate the analysis of both polar and non-polar substances.
  • Recrystallization agent for purifying active pharmaceutical ingredients (APIs) due to its ability to dissolve many organic compounds.

General description

Chloroform is a volatile liquid that serves as a versatile solvent in high-performance liquid chromatography (HPLC) and a variety of analytical techniques. Its unique properties, including moderate UV absorbance and excellent solvating capabilities, make it ideal for extracting and purifying diverse chemical compounds.

Packaging

M-Bottle for Solvents
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Preparation Note

Product filtered through a 0.2 μm filter

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

target_organs

Central nervous system, Liver,Kidney

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

does not flash

flash_point_c

does not flash

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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