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Merck

MABX1911

Anti-human IgM (10mg) KC

from mouse

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-human IgM (10mg) KC, from mouse

biological source

mouse

antibody form

purified antibody

antibody product type

secondary antibodies

clone

monoclonal

species reactivity

human

technique(s)

ELISA: suitable
immunodiffusion: suitable

isotype

IgG1

Related Categories

Analysis Note

Tested

Application

Detect Human Serum IgM using this mouse monoclonal, Cat. No. MABX1911-10KC, validated for use in and ELISA and Lateral Flow Assay.
None
Research Category
Secondary & Control Antibodies

Biochem/physiol Actions

Immunoglobulin M (IgM) plays a key role in engulfing the apoptotic cells. The reduction in serum IgM levels leads to increased autoimmune response and a higher risk of infections. IgM exhibits polyreactive and autoreactive functionality. A defect in IgM production is observed in X-linked agammaglobulinemia.
Specific for Human IgM. No cross reactivity with human IgA, IgD, IgE or IgG.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Secondary antibody specific for Human Immunoglobulin M
Immunoglobulin M (IgM) is a highly conserved antibody in vertebrates and is expressed early during development of immune system. It is present as a pentamer in the serum and is secreted by peritoneal B cells.

Immunogen

corresponding to Human Human Serum IgM.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Format: Purified
Ion-exchange chromatography
Purified mouse monoclonal in buffer containing 50 mM NaCl, 10 mM PBS, pH 8.0, 0.1 % sodium azide (NaN₃).

Preparation Note

2-8°C. For long-term storage, freeze at -20°C.

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Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Structure and function of immunoglobulins.
Schroeder Jr HW and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
The importance of natural IgM: scavenger, protector and regulator
Ehrenstein MR and Notley CA
Nature Reviews: Immunology, 10(11), 778-786 (2010)
Protective roles of natural IgM antibodies
Gronwall C, et al.
Frontiers in immunology, 3, 66-66 (2012)
Caroline Grönwall et al.
Frontiers in immunology, 3, 66-66 (2012-05-09)
Antibodies are a vital part of the armamentarium of the adaptive immune system for the fine-tuning of the recognition and response to foreign threats. However, in health there are some types of antibodies that instead recognize self-antigens and these contribute
Harry W Schroeder et al.
The Journal of allergy and clinical immunology, 125(2 Suppl 2), S41-S52 (2010-03-05)
Immunoglobulins are heterodimeric proteins composed of 2 heavy and 2 light chains. They can be separated functionally into variable domains that bind antigens and constant domains that specify effector functions, such as activation of complement or binding to Fc receptors.

Related Content

Products and support for mpox research, offering world-class reagents for immunoassay and molecular assay development.

Global Trade Item Number

SKUGTIN
MABX1911-1KC04054839490262
MABX1911-10KC04054839490255

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