Bis(cyclohexanone)oxaldihydrazone

Name: Bis(cyclohexanone)oxaldihydrazone
Brand: SIAL

for spectrophotometric det. of Cu, ≥99.0%

Synonym(s):

Cuprizon, Cuprizone, Oxalic acid bis(cyclohexylidenehydrazide)

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₂N₄O₂

CAS Number:

370-81-0

Molecular Weight:

278.35

UNSPSC Code:

41116105

NACRES:

NA.21

PubChem Substance ID:

329750579

EC Number:

206-729-2

Beilstein/REAXYS Number:

2388004

MDL number:

MFCD00001659

Product Name

Bis(cyclohexanone)oxaldihydrazone, for spectrophotometric det. of Cu, ≥99.0%

InChI key

DSRJIHMZAQEUJV-UHFFFAOYSA-N

InChI

1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)

SMILES string

O=C(N\N=C1\CCCCC1)C(=O)N\N=C2/CCCCC2

assay

≥99.0% (N)
≥99.0%

form

powder

quality

for spectrophotometric det. of Cu

technique(s)

UV/Vis spectroscopy: suitable

mp

210-214 °C (lit.)
210-214 °C

Quality Level

100

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Related Categories

Analytical Chemistry

Analytical Reagents

Chromatography & Spectroscopy Reagents

Application

Cuprizone (Bis(cyclohexanone)oxaldihydrazone) was used for toxic demyelination in the central nervous system in order to investigate the pathobiology of remyelination in the corpus callosum, so as to study the human demyelinating diseases such as multiple sclerosis. It was also used a model to study components of neuroinflammation.

General description

Cuprizone (Bis(cyclohexanone)oxaldihydrazone) is a physically unstable compound and is a well-known neurotoxic agent.

Other Notes

For the spectrophotometric determination of Cu(II)

In the presence of a copper salt, this ligand catalyzes Ullmann-type C-N bond forming reactions under mild, aqueous conditions.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Zhu, X., et al.

Synthesis, 23, 3955-3962 (2006)

Cuprizone treatment induces distinct demyelination, astrocytosis, and microglia cell invasion or proliferation in the mouse cerebellum.

Groebe A

Cerebellum, 8 (3), 163-174 (2009)

Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent.

Thomas S

The American Journal of Pathology, 174 (4), 1053-1061 (2008)

R.K. Rohde

Analytical Chemistry, 38, 911-911 (1966)

The protective role of nitric oxide in a neurotoxicant-induced demyelinating model.

Arnett H

Journal of Immunology, 168 (1), 427-433 (2002)

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