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Merck

31493

Sodium salicylate

99.5-101.0% (calc. to the dried substance), puriss. p.a., reag. Ph. Eur.

Synonym(s):

2-Hydroxybenzoic acid sodium salt, Salicylic acid sodium salt, Sodium 2-hydroxybenzoate

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About This Item

Linear Formula:
HOC6H4COONa
CAS Number:
54-21-7
Molecular Weight:
160.10
NACRES:
NA.21
PubChem Substance ID:
57648580
UNSPSC Code:
12352100
EC Number:
200-198-0
MDL number:
MFCD00002440
Beilstein/REAXYS Number:
3732792
assay:
99.5-101.0% (calc. to the dried substance)

Product Name

Sodium salicylate, puriss. p.a., reag. Ph. Eur., 99.5-101.0% (calc. to the dried substance)

InChI

1S/C7H6O3.Na/c8-6-4-2-1-3-5(6)7(9)10;/h1-4,8H,(H,9,10);/q;+1/p-1

InChI key

ABBQHOQBGMUPJH-UHFFFAOYSA-M

SMILES string

[Na+].Oc1ccccc1C([O-])=O

agency

USP/NF
reag. Ph. Eur.

grade

puriss. p.a.

assay

99.5-101.0% (calc. to the dried substance)

impurities

acidic reac. impurities, complies
 sulfite or thiosulfate, complies
≤0.001% heavy metals (as Pb)

loss

≤0.3% loss on drying, 105 °C

mp

>300 °C (lit.)

anion traces

chloride (Cl-): ≤20 mg/kg
sulfate (SO42-): ≤500 mg/kg

cation traces

Fe: ≤10 mg/kg

suitability

in accordance for appearance of solution

Quality Level

100

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Application

Sodium salicylate may be used as phenolic reagent in salicylate method for the determination of ammonia. It may be employed as a hydrotropic agent to study the release of anticancer drug camptothecin (CPT) from mixed micelles.

General description

Sodium salicylate can be prepared from the reaction of salicylic acid and ammonia. It exhibits fluorescence at higher concentrations and effectively absorbs β-particles. Due to these properties, it has been employed as fluor for the radioactivity detection in various gels.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

208.9 °F - Pensky-Martens closed cup

flash_point_c

98.3 °C - Pensky-Martens closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB5217
SDBB2858
SDBB2528
STBL4722
STBL4097

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Yan Gao et al.
Colloids and surfaces. B, Biointerfaces, 64(2), 194-199 (2008-03-08)
To increase the solubility and cytotoxicity of poorly soluble anticancer drug camptothecin (CPT), mixed micelles made of Pluronic P105 (P105) and d-alpha-tocopheryl polyethylene glycol 1,000 succinate (TPGS) were prepared. The interaction of Pluronic and TPGS was studied and critical micelle
Ammonia determination based on indophenol formation with sodium salicylate.
Verdouw H, et al.
Water Research, 12(6), 399-402 (1978)
Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate.
J P Chamberlain
Analytical biochemistry, 98(1), 132-135 (1979-09-15)
Kui Wang et al.
Journal of medicinal chemistry, 52(20), 6402-6412 (2009-10-16)
Viologens are showing an increasing number of scientific and technical applications in addition to their use as herbicides. However, their high toxicity poses considerable risks to human health, society, and the environment. In this context, we propose a new therapeutic
Astam K Patra et al.
Journal of hazardous materials, 201-202, 170-177 (2011-12-16)
We report a highly efficient synthetic strategy for self-assembled mesoporous γ-Al(2)O(3) materials using sodium salicylate as template. The mesoporous γ-Al(2)O(3) samples synthesized following this strategy have high surface areas (231-497 m(2)g(-1)), consist of crystalline tiny spherical nanoparticles of dimensions ca.
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