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Merck

46706

Pyrimethamine

VETRANAL®, analytical standard

Synonym(s):

5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine

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About This Item

Empirical Formula (Hill Notation):
C12H13ClN4
CAS Number:
58-14-0
Molecular Weight:
248.71
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329756622
EC Number:
200-364-2
Beilstein/REAXYS Number:
219864
MDL number:
MFCD00057350

Product Name

Pyrimethamine, VETRANAL®, analytical standard

InChI

1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)

SMILES string

CCC1=NC(N)=NC(N)=C1C2=CC=C(Cl)C=C2

InChI key

WKSAUQYGYAYLPV-UHFFFAOYSA-N

grade

analytical standard

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

clinical testing

format

neat

Quality Level

200

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG3736
BCBZ7909
BCBW3017

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Sophie Rogée et al.
Antiviral research, 161, 1-9 (2018-10-28)
Rabies virus transmits from animals to humans and causes encephalitis. Every year more than 15 million people receive a post exposure prophylaxis (PEP) treatment that is highly effective in the prevention of rabies disease. However, when clinical symptoms appear, for
Shuxian Liu et al.
Parasites & vectors, 13(1), 242-242 (2020-05-13)
Toxoplasma gondii is a zoonotic pathogen that causes toxoplasmosis and leads to serious public health problems in developing countries. However, current clinical therapeutic drugs have some disadvantages, such as serious side effects, a long course of treatment and the emergence
Xiyuan Yao et al.
Scientific reports, 10(1), 15201-15201 (2020-09-18)
Cytotoxic drugs that are mechanistically distinct from current chemotherapies are attractive components of personalized combination regimens for combatting aggressive forms of cancer. To gain insight into the cellular mechanism of a potent platinum-acridine anticancer agent (compound 1), a correlation analysis
Anna Maria van Eijk et al.
The Lancet. Infectious diseases, 13(12), 1029-1042 (2013-09-24)
Pregnant women in malaria-endemic countries in sub-Saharan Africa are especially vulnerable to malaria. Recommended prevention strategies include intermittent preventive treatment with two doses of sulfadoxine-pyrimethamine and the use of insecticide-treated nets. However, progress with implementation has been slow and the
Inbarani Naidoo et al.
Trends in parasitology, 29(10), 505-515 (2013-09-14)
Sulfadoxine-pyrimethamine (SP) is used throughout Africa for intermittent preventive treatment (IPT) of malaria, but resistance threatens its efficacy. We found marked regional differences in the genotypes responsible for SP resistance when mapping recent surveys of dihydrofolate reductase (dhfr) and dihydropteroate
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