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Merck

73658

Ginsenoside Rh2

analytical standard

Synonym(s):

(3β,12β)-12,20-Dihydroxydammar-24-en-3-yl-β-D-glucopyranoside, 20(S)-Ginsenoside-Rh2

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About This Item

Empirical Formula (Hill Notation):
C36H62O8
CAS Number:
78214-33-2
Molecular Weight:
622.87
NACRES:
NA.24
PubChem Substance ID:
329765120
UNSPSC Code:
85151701
MDL number:
MFCD00800712

Product Name

Ginsenoside Rh2, analytical standard

InChI

1S/C36H62O8/c1-20(2)10-9-14-36(8,42)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(32(3,4)24(33)12-17-34(25,35)6)44-31-30(41)29(40)28(39)23(19-37)43-31/h10,21-31,37-42H,9,11-19H2,1-8H3/t21-,22+,23+,24-,25+,26-,27-,28+,29-,30+,31-,33-,34+,35+,36-/m0/s1

SMILES string

C\C(C)=C/CC[C@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]3[C@@]4(C)CC[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(C)(C)[C@@H]4CC[C@@]23C

InChI key

CKUVNOCSBYYHIS-IRFFNABBSA-N

grade

analytical standard

assay

≥97.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

2-8°C

Quality Level

100

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Application

Ginsenoside Rh2 may be used as an analytical reference standard for the quantification of the analyte in plasma samples using high-performance liquid chromatography technique.[24]
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

General description

Ginsenoside Rh2 is an active component of Red P. ginseng. It is reported to be obtained as a metabolite of ginsenoside Rg3, when anaerobically incubated with human fecal microflora.

Other Notes

This compound is commonly found in plants of the genus: panax

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN7115
BCCM5602
BCCH1115
BCCG0514
BCBV9500

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Ben-Dong Fu et al.
Fitoterapia, 84, 303-307 (2012-12-26)
Ginsenoside Rh2 is one of the most important ginsenosides in ginseng with antitumor, antidiabetic, antiallergic, and anti-inflammatory effects. However, the extremely poor oral bioavailability induced by its low water solubility greatly limits the potency of Rh2 in clinical use. Therefore
Y Wang et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 44(1), 33-40 (2011-12-30)
The present study was designed to determine the antihyperglycemic function of ginsenoside Rh2 (GS-Rh2) by the regeneration of β-cells in mice that underwent 70% partial pancreatectomy (PPx), and to explore the mechanisms of GS-Rh2-induced β-cell proliferation. Adult C57BL/6J mice were
Yong-Sheng Jiang et al.
International journal of molecular medicine, 26(6), 787-793 (2010-11-03)
Herbal remedies containing root extracts of Panax ginseng are commonly used for complementary or alternative therapies. Ginsenosides, the major components of root extracts, are responsible for ginseng's pharmacological and biological effects; however, their mechanisms of action are unclear. We examined
Chunjing Zhang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(12), 1670-1674 (2011-10-20)
To evaluate and explore the effects of 20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2 on the cytotoxicity, proliferation and the apoptosis of human lung adenocarcinoma A549 cells, and to illustrate the structure-activity relationship and possible mechanisms of anti-tumor active ingredients of ginseng.
Alain G Musende et al.
The Prostate, 70(13), 1437-1447 (2010-08-06)
Docetaxel is one of the few chemotherapeutic drugs that are considered highly effective when used to treat prostate cancer patients that have relapsed and/or metastatic disease, it is therefore reasonable to expect further improvements in treatment outcomes when it is
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