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Merck

76899

Temozolomide

VETRANAL®, analytical standard

Synonym(s):

3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide, 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide, 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, NSC 362856

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About This Item

Empirical Formula (Hill Notation):
C6H6N6O2
CAS Number:
85622-93-1
Molecular Weight:
194.15
NACRES:
NA.24
PubChem Substance ID:
329767423
UNSPSC Code:
41116107
MDL number:
MFCD00866492

Product Name

Temozolomide, VETRANAL®, analytical standard

InChI

1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)

SMILES string

CN1N=Nc2c(ncn2C1=O)C(N)=O

InChI key

BPEGJWRSRHCHSN-UHFFFAOYSA-N

grade

analytical standard

product line

VETRANAL®

assay

≥99.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

ign. residue

≤0.2%

loss

≤0.5% loss on drying

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

Quality Level

100

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
TMZ may be used as a reference standard for the analysis of temozolomide in serum and brain tumor samples by micellar electrokinetic capillary chromatography (MEKC), in aqueous solutions by liquid chromatography-electrospray-tandem mass spectrometry (LC-ESI-MS/MS), in active pharmaceutical ingredients (APIs) by high performance liquid chromatography (HPLC) with MS/MS and in pharmaceutical dosage form by HPLC equipped with photodiode array (PDA) detector.

General description

Temozolomide (TMZ) is an alkylating agent of the imidazotetrazine derivatives that shows broad-spectrum antitumor activity against murine tumors.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM7332
BCCJ1063
BCCD1236

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Stability of sample solution as a crucial point during HPLC determination of chemical purity of temozolomide drug substance
Jedynak L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 83(23), 19-27 (2013)
Determination of temozolomide in serum and brain tumor with micellar electrokinetic capillary chromatography.
Andrasi M, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 879(23), 2229-2233 (2011)
Development and Validation of Simultaneous Detrmination of Anastrozole and Temozolomide in Pharmaceutical Dosage Forms.
Daphal VN, et al.
International Journal of Theoretical & Applied Sciences, 4(23), 48-55 (2012)
Multianalyte determination of 24 cytostatics and metabolites by liquid chromatography-electrospray-tandem mass spectrometry and study of their stability and optimum storage conditions in aqueous solution.
Negreira N, et al.
Talanta, 116(23), 290-299 (2013)
High-performance liquid chromatographic analysis and stability of anti-tumor agent temozolomide in human plasma.
Kim H, et al.
Journal of Pharmaceutical and Biomedical Analysis, 24(3), 461-468 (2001)
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