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Merck

81172

Poly(ethylene glycol)

greener alternative

tested according to Ph. Eur., 400

Synonym(s):

Macrogol 400, Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
25322-68-3
NACRES:
NA.21
PubChem Substance ID:
24887676
UNSPSC Code:
12352104
MDL number:
MFCD00081839

Product Name

Poly(ethylene glycol), tested according to Ph. Eur., 400

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

SMILES string

C(CO)O

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

agency

tested according to Ph. Eur.

form

liquid

mol wt

380-420

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

application(s)

pharmaceutical (small molecule)

greener alternative category

Aligned

Quality Level

200

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Application

Poly(ethylene glycol) has been used as a liquid medium to prepare shear thickening fluid (STF) by directly mixing it with fumica silica.

Biochem/physiol Actions

Polyethylene glycol (PEG) is a synthetic polymer and is used as an additive in food, cosmetics, and pharmaceuticals. It is also involved in biomedical applications like biosensing, imaging, and tissue engineering. PEG is used as a gold standard in bioconjugation and nanomedicine thereby increasing blood circulation time and improving drug efficacy. PEG-conjugated drugs are approved by the U.S. Food and Drug Administration (FDA). They are considered safe for use in humans. PEG reduces the liver uptake and repels protein adsorption, which makes it useful in nanocoating.

General description

Polyethylene glycol (PEG) is a polyether compound with repeated ethylene glycol units[-(CH2CH2O)n].
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Polyethylene glycol (PEG) is an eco-friendly, biodegradable polymer widely used in pharmaceuticals and cosmetics. Its non-toxic nature and versatility make it a sustainable choice, derived from renewable resources, contributing to greener product formulations. Click here for more information.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5369
BCCN1853
BCCM9895
BCCM9428
BCCM4477

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The ballistic performance of aramid based fabrics impregnated with multi-phase shear thickening fluids
Gurgen S and Kucshan MC
Polymer Testing, 64, 296-306 (2017)
The rheology of shear thickening fluids with various ceramic particle additives
Gurgen S, et al.
Materials & Design, 104, 312-319 (2016)
The stab resistance of fabrics impregnated with shear thickening fluids including various particle size of additives
Gurgen S and Kucshan MC
Composites Part A: Applied Science and Manufacturing, 94, 50-60 (2017)
Anisha A D'souza et al.
Expert opinion on drug delivery, 13(9), 1257-1275 (2016-04-28)
Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties and well-established safety profile: prime requisites considered during the selection of any excipient in formulation development. The unique
Janina-Miriam Noy et al.
Biomacromolecules, 21(6), 2320-2333 (2020-04-29)
Phosphorylcholine is known to repel the absorption of proteins onto surfaces, which can prevent the formation of a protein corona on the surface of nanoparticles. This can influence the fate of nanoparticles used for drug delivery. This material could therefore
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