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Merck

A1968

Ascorbic acid 6-palmitate

meets USP testing specifications

Synonym(s):

6-O-Palmitoyl-L-ascorbic acid, L-Ascorbic acid 6-hexadecanoate, L-Ascorbyl palmitate, Ascorbic acid 6-palmitate, NSC 402451

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About This Item

Empirical Formula (Hill Notation):
C22H38O7
CAS Number:
137-66-6
Molecular Weight:
414.53
UNSPSC Code:
12352205
NACRES:
NA.21
PubChem Substance ID:
24890608
EC Number:
205-305-4
Beilstein/REAXYS Number:
96552
MDL number:
MFCD00005377

Key Documents

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InChI key

QAQJMLQRFWZOBN-LAUBAEHRSA-N

InChI

1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1

SMILES string

CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O

biological source

synthetic

agency

USP/NF, meets USP testing specifications

assay

95.0-100.5%

form

powder

color

light yellow

application(s)

pharmaceutical (small molecule)

Quality Level

200

Related Categories

General description

Ascorbic acid 6-palmitate/L-Ascorbyl 6-palmitate (AP) is a derivative of a synthetic lipophilic ascorbic acid.

Biochem/physiol Actions

L-Ascorbyl 6-palmitate (AP) is used as preservative in foods. In mice, AP works as a dietary antitumor promoter. 

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000522022
0000522022
0000511396
0000511396
0000494065

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A comparison of L-ascorbic acid and L-ascorbyl 6-palmitate utilization in Guinea Pigs and humans
Johnston CS, et al.
Nutrition Research (New York, N.Y.), 14(10), 1465-1471 (1994)
Raju Jukanti et al.
Journal of microencapsulation, 28(2), 142-149 (2011-01-27)
The aim of this study is to develop ascorbyl palmitate (ASP) loaded doxorubicin (DOX) pegylated liposomes and to evaluate their targeting potential to tumor. We have prepared conventional (DL), pegylated DOX liposomes with (SDL) and without ascorbyl palmitate (SDL-A). The
Lindomar A Lerin et al.
Ultrasonics sonochemistry, 18(5), 988-996 (2011-01-29)
This work is focused on the optimization of reaction parameters for the synthesis of ascorbyl palmitate catalyzed by Candida antarctica lipase in different organic solvents under ultrasound irradiation. The sequential strategy of experimental design proved to be useful in determining
Milagro Mottola et al.
Biochimica et biophysica acta, 1828(11), 2496-2505 (2013-06-29)
Ascorbyl palmitate (ASC16) is an anionic amphiphilic molecule of pharmacological interest due to its antioxidant properties. We found that ASC16 strongly interacted with model membranes. ASC16 penetrated phospholipid monolayers, with a cutoff near the theoretical surface pressure limit. The presence
Chen-Yuan Hsiao et al.
Frontiers in endocrinology, 11, 613-613 (2020-10-06)
Calcitonin is a small peptide hormone secreted from the parafollicular cells of the thyroid gland in response to an increase in serum calcium. The inhibition of osteoclastic resorption is the main mechanism by which calcitonin quickly decreases circulating calcium levels.
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