B0770

Brilliant Blue G

Name: Brilliant Blue G
Brand: SIAL

≥80% purity (HPLC), powder

Synonym(s):

Acid blue 90, Coomassie Brilliant Blue G

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About This Item

Empirical Formula (Hill Notation):

C₄₇H₄₈N₃NaO₇S₂

CAS Number:

6104-58-1

Molecular Weight:

854.02

UNSPSC Code:

12171500

NACRES:

NA.47

PubChem Substance ID:

24891535

EC Number:

228-058-4

MDL number:

MFCD00078482

Colour Index Number:

42655

Beilstein/REAXYS Number:

5230822

Product Name

Brilliant Blue G, pure

InChI key

RWVGQQGBQSJDQV-UHFFFAOYSA-M

InChI

1S/C47H49N3O7S2.Na/c1-6-49(31-35-11-9-13-43(29-35)58(51,52)53)40-21-25-45(33(4)27-40)47(37-15-17-38(18-16-37)48-39-19-23-42(24-20-39)57-8-3)46-26-22-41(28-34(46)5)50(7-2)32-36-12-10-14-44(30-36)59(54,55)56;/h9-30H,6-8,31-32H2,1-5H3,(H2,51,52,53,54,55,56);/q;+1/p-1

SMILES string

[Na+].CCOc1ccc(Nc2ccc(cc2)C(\c3ccc(cc3C)N(CC)Cc4cccc(c4)S([O-])(=O)=O)=C5\C=CC(\C=C5C)=[N+](\CC)Cc6cccc(c6)S([O-])(=O)=O)cc1

assay

≥80.0% (HPLC)

form

powder

technique(s)

microbe id | staining: suitable

color

dark violet

solubility

H₂O: 1 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

200

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Related Categories

Clinical & Diagnostics

Hematology Stains

Histology Stains

Tissue Diagnostics

Application

Brilliant Blue G has been used for determining the urine protein concentration. It has been used for the protein band detection after SDS-PAGE (sodium dodecyl sulfate polyacrylamide gel electrophoresis). It has been used as a P2X7R (purinergic receptor) antagonist.

Biochem/physiol Actions

Brilliant Blue G is used for staining protein(s) in polyacrylamide gels. It is also a P2X7 purinergic receptor antagonist. The receptor is mainly involved in neuroinflammatory events. In human SOD1G93A amyotrophic lateral sclerosis mouse, administration of brilliant blue G reduces body weight loss. However, it does not affect survival or motor coordination in transgenic mice.

P2X7 purinergic receptor antagonist.

Legal Information

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Melatonin attenuates hypertension-induced renal injury partially through inhibiting oxidative stress in rats.

Qiao YF, et al.

Molecular Medicine Reports, 13, 21-21 (2016)

P2X7 antagonism using Brilliant Blue G reduces body weight loss and prolongs survival in female SOD1G93A amyotrophic lateral sclerosis mice.

PeerJ, e3064-e3064 (2017)

MATE transport of the E. coli-derived genotoxin colibactin.

Mousa JJ, et al.

Nature microbiology, 1, 15009-15009 (2016)

Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective.

Lim JC, et al.

Frontiers in Cellular Neuroscience, 10, 270-270 (2016)

COMPARATIVE EVALUATION OF SOMATIC PROTEINS OF THE NYMPHAL STAGE OF LINGUATULA SERRATA ISOLATED FROM GOATS AND CATTLE IN NORTHWEST IRAN.

Bulgarian Journal of Veterinary Medicine, 19, 242-246 (2016)

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Protocols

Hand-casting gels for PAGE and SDS-PAGE using mPAGE® TurboMix Bis-Tris Gel Casting Kits

Simplify your SDS-PAGE gel preparation with our pre-mixed solutions and protocols to achieve precise protein separation.

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