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Merck

C5070

CHAPS hydrate

BioXtra, ≥98% (TLC)

Synonym(s):

3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate hydrate, CHAPS

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About This Item

Empirical Formula (Hill Notation):
C32H58N2O7S · xH2O
CAS Number:
331717-45-4
Molecular Weight:
614.88 (anhydrous basis)
NACRES:
NA.21
PubChem Substance ID:
24892750
UNSPSC Code:
12161900
MDL number:
MFCD00012116

Product Name

CHAPS hydrate, BioXtra, ≥98% (TLC)

InChI key

SJCUTFKCLFLIFE-JWTJKVBLSA-N

SMILES string

O.C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI

1S/C32H58N2O7S.H2O/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36;/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41);1H2/t21-,22+,23-,24-,25+,26+,27-,28+,30+,31+,32-;/m1./s1

description

zwitterionic

product line

BioXtra

assay

≥98% (TLC)

form

powder

mol wt

614.88 g/mol (anhydrous basis)

technique(s)

protein purification: suitable
protein quantification: suitable

impurities

≤0.001% Phosphorus (P)
≤0.1% Insoluble matter
<0.04% DMF

ign. residue

≤0.1%

mp

157 °C (dec.) (lit.)

solubility

H2O: 0.1 M, clear, colorless

anion traces

chloride (Cl-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

Quality Level

400

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Application

  • 10mM CHAPS detergent has been used in the process of ion-exchange chromatography for improved purification.
  • 0.5 w/v of CHAPS is a component of high salt buffer in protein purification alongside HEPES, NaCl and EDTA.
  • HEPES buffer has been used as lysis buffer in immunoprecipitation, supplemented with 1% CHAPS.

General description

CHAPS is a non-denaturing, zwitterionic sulfobetaine detergent. It is mild and solubilizes membrane proteins and receptors. It is useful for breaking protein-protein interactions. It is a derivative of the naturally occurring bile salts. It has small micellar molecular weight (6,150) and high critical micellar concentration (6 - 10 mM) allowing it to be removed from samples by dialysis.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000510825
0000510825
0000502063
0000501550
0000501550

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