C7731

Caffeine

Name: Caffeine
Brand: SIAL

meets USP testing specifications, anhydrous

Synonym(s):

1,3,7-Trimethylxanthine

Select a Size

All Photos(2)

About This Item

Empirical Formula (Hill Notation):

C₈H₁₀N₄O₂

CAS Number:

58-08-2

Molecular Weight:

194.19

UNSPSC Code:

12352210

NACRES:

NA.21

PubChem Substance ID:

24892984

EC Number:

200-362-1

Beilstein/REAXYS Number:

17705

MDL number:

MFCD00005758

grade:

anhydrous

agency:

USP/NF
meets USP testing specifications

Product Name

Caffeine, meets USP testing specifications, anhydrous

InChI key

RYYVLZVUVIJVGH-UHFFFAOYSA-N

InChI

1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

SMILES string

CN1C(=O)N(C)c2ncn(C)c2C1=O

grade

anhydrous

agency

USP/NF
meets USP testing specifications

form

crystalline
powder

mp

234-236.5 °C (lit.)

solubility

H₂O: soluble 18.7 g/L at 16 °C

Quality Level

200

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142)
mouse ... Adora2b(11541)
rat ... Adora1(29290), Adora2a(25369)

Looking for similar products? Visit Product Comparison Guide

Application

Caffeine has been used:

to functionally disable Ca²⁺ removal via sarco/endoplasmic reticulum Ca²⁺ ATPase (SERCA)
to determine its effects in overcoming excitation-contraction-coupling failure
to compare its role as a stimulant with guarana

General description

Caffeine is a commonly consumed pharmacologically active substance. It is a member of the class of methylxanthines. It is a natural alkaloid found in coffee, cocoa and other plants. Caffeine might be linked to osteoporosis, cardiovascular risk, arrhythmia and gastrointestinal disturbances. Caffeine is used to treat orthostatic hypotension, bronchopulmonary dysplasia and apnea of prematurity (AOP).

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000490122

0000517926

0000517927

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Caffeine?s beneficial effect on maximal voluntary strength and activation in uninjured but not injured muscle

Park ND, et al.

International Journal of Sport Nutrition and Exercise Metabolism, 18(6), 639-652 (2008)

There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes

Devenyi RA and Sobie EA

Journal of Molecular and Cellular Cardiology, 96, 38-48 (2016)

Orthostatic hypotension in the elderly: diagnosis and treatment

Gupta V and Lipsitz LA

The American Journal of Medicine, 120(10), 841-847 (2007)

There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes.

Ryan A Devenyi et al.

Journal of molecular and cellular cardiology, 96, 38-48 (2015-08-04)

While many ion channels and transporters involved in cardiac cellular physiology have been identified and described, the relative importance of each in determining emergent cellular behaviors remains unclear. Here we address this issue with a novel approach that combines population-based

Effects of caffeine on human health

Nawrot P, et al.

Food Additives and Contaminants, 20(1), 1-30 (2003)

View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service