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Merck

I114

p-Iodoclonidine hydrochloride

analytical standard, for drug analysis

Synonym(s):

2-[(2,6-Dichloro-4-iodophenyl)imino]imidazoline hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H8Cl2IN3 · HCl
CAS Number:
108294-53-7
Molecular Weight:
392.45
NACRES:
NA.24
PubChem Substance ID:
329815344
UNSPSC Code:
41116107
MDL number:
MFCD00069292

Key Documents

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Product Name

p-Iodoclonidine hydrochloride, analytical standard, for drug analysis

InChI

1S/C9H8Cl2IN3.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2H2,(H2,13,14,15);1H

SMILES string

Cl[H].Clc1cc(I)cc(Cl)c1\N=C2/NCCN2

InChI key

ULCGXOSKNHMYAX-UHFFFAOYSA-N

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white to off-white

solubility

H2O: soluble

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

100

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Related Categories

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

High affinity α2 adrenergic receptor agonist.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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P Ernsberger et al.
The Journal of pharmacology and experimental therapeutics, 264(1), 172-182 (1993-01-01)
Both the hypotension and the sedation elicited by centrally acting antihypertensive agents are traditionally attributed to activation of alpha 2 adrenergic receptors. Second-generation centrally acting agents such as moxonidine are less sedating but retain antihypertensive efficacy. A novel receptor which
M A Gerhardt et al.
Molecular pharmacology, 38(2), 214-221 (1990-08-01)
The binding properties of p-[125I]iodoclonidine [( 125I]PIC) to human platelet membranes and the functional characteristics of PIC are reported. [125I]PIC bound rapidly and reversibly to platelet membranes, with a first-order association rate constant (kon) at room temperature of 8.0 +/-
J E Piletz et al.
The Journal of pharmacology and experimental therapeutics, 279(2), 694-702 (1996-11-01)
To identify selective compounds for nonadrenergic I1-imidazoline receptors (I1), the affinities of 22 ligands for [125I]p-iodoclonidine binding have been compared at human platelet I1-imidazoline binding sites (analyzed under norepinephrine mask of alpha-2 AR) and at human alpha-2A, alpha-2B and alpha-2C
Y Jin et al.
Investigative ophthalmology & visual science, 35(5), 2500-2508 (1994-04-01)
This study sought to identify and characterize subtypes of alpha 2-adrenoceptors in rabbit ciliary body. Radioligand binding assays were performed with the alpha 2-agonist ligand [125I]-p-iodoclonidine ([125I]PIC) and the antagonist ligand [3H]rauwolscine. Both [125I]PIC and [3H]rauwolscine bound to a single
J E Piletz et al.
The Journal of pharmacology and experimental therapeutics, 267(3), 1493-1502 (1993-12-01)
Human platelets are shown to possess at least two high-affinity, imidazol(in)e-preferring binding sites that are pharmacologically distinct from alpha-2 adrenoceptors. These nonadrenergic sites were radiolabeled even in the presence of a 10 microM norepinephrine mask of alpha-2 adrenoceptors. Heterogeneity at
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