M8010

N,N′-Dimethyl-9,9′-biacridinium dinitrate

Name: <I>N,N</I>′-Dimethyl-9,9′-biacridinium dinitrate
Brand: SIAL

Powder

Synonym(s):

9,9′-Bis(N-methylacridinium nitrate), Lucigenin

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All Photos(4)

About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₂N₄O₆

CAS Number:

2315-97-1

Molecular Weight:

510.50

NACRES:

NA.47

PubChem Substance ID:

24897210

UNSPSC Code:

12171500

EC Number:

219-023-4

MDL number:

MFCD00011925

Beilstein/REAXYS Number:

3901768

Product Name

N,N′-Dimethyl-9,9′-biacridinium dinitrate, used as chemiluminescent reagent

InChI key

KNJDBYZZKAZQNG-UHFFFAOYSA-N

InChI

1S/C28H22N2.2NO3/c1-29-23-15-7-3-11-19(23)27(20-12-4-8-16-24(20)29)28-21-13-5-9-17-25(21)30(2)26-18-10-6-14-22(26)28;2*2-1(3)4/h3-18H,1-2H3;;/q+2;2*-1

SMILES string

[O-][N+]([O-])=O.[O-][N+]([O-])=O.C[n+]1c2ccccc2c(-c3c4ccccc4[n+](C)c5ccccc35)c6ccccc16

form

powder

mp

245-250 °C

solubility

acetic acid: 10 mg/mL

fluorescence

λ_ex 319 nm; λ_em 384 nm (pH 9.0)
λ_ex 360 nm; λ_em 449 nm (Reaction product)
λ_ex 368 nm; λ_em 505 nm in H₂O

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

Quality Level

100

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Related Categories

Clinical & Diagnostics

Hematology Stains

Histology Stains

Tissue Diagnostics

Application

N,N′-Dimethyl-9,9′-biacridinium dinitrate has been used in chemiluminescence assay to measure reactive oxygen species production and superoxide production.

Reagent used for the generation of chemiluminescence in the presence of a reductant and oxygen; it is employed in numerous chemiluminescent assays. Lucigenin is specific for superoxide anion radical.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Neutrophil superoxide release and plasma C-reactive protein levels pre- and post-periodontal therapy.

Ling MR

Journal of Clinical Periodontology, 43, 652-652 (2016)

Survival and in vitro fertility of boar spermatozoa frozen in the presence of superoxide dismutase and/or catalase.

Roca J

Journal of Andrology, 26, 15-15 (2005)

The role of flagella and chemotaxis genes in host pathogen interaction of the host adapted Salmonella enterica serovar Dublin compared to the broad host range serovar S. Typhimurium.

John Elmerdahl Olsen et al.

BMC microbiology, 13, 67-67 (2013-03-28)

The importance of flagella and chemotaxis genes in host pathogen interaction in Salmonella enterica is mainly based on studies of the broad host range serovar, S. Typhimurium, while little is known on the importance in host specific and host adapted

LPS-induced renal inflammation is prevented by (-)-epicatechin in rats.

Paula Denise Prince et al.

Redox biology, 11, 342-349 (2017-01-01)

This work investigated the capacity of (-)-epicatechin to prevent the renal damage induced by LPS administration in rats. Male Sprague Dawley rats were fed for 4 days a diet without or with supplementation with (-)-epicatechin (80mg/kg BW/d), and subsequently i.p.

Toll-like receptor-4 is involved in eliciting an LPS-induced oxidative burst in neutrophils

Remer KA, et al.

Immunology Letters, 85, 75-80 (2003)

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