Ru Phos

Welcome to our ISOM8^™ line of high-quality products available and able to scale for manufacturing. Within our ISOM8^™ team, we have expertise and documentation to support ISO 9001 industrial and non-GMP pharma production needs, as defined by our M-Clarity^™ Program.


Our portfolio of ISOM8^™ products and chemistries is ever evolving to support our valued Sigma-Aldrich customers′ requirements. Please navigate to our documents section to look at dossiers and other quality documentation for this product, provided with support of our Elevate Program.

We are committed to bringing you Greener Alternative Products, which adhere to one of the ">four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Atom Economy” and “Design for Energy Efficiency”. Click here to view its DOZN scorecard.

Buchwald Phosphine Ligands forchemical Synthesis


Common applications


RuPhos developed by the Buchwald group, RuPhos and its palladium precatalyst forms are notable for being air-stable, moisture-stable,and highly soluble, enabling efficient catalysis with lower catalyst loadings and shorter reaction times in organic synthesis.


Notable characteristics & key uses:

• Steric & Electronic Properties: RuPhos′s biaryl structure with 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl configuration provides stability and selectivity. Its electron-rich phosphine and isopropoxy groups enhance catalytic reactivity and substrate compatibility.


• Metal Binding: Excels in palladium and nickel-catalyzed processes including Suzuki-Miyaura coupling and Buchwald-Hartwig amination. Has a smaller Tolman cone angle than BrettPhos,donating less electron density to metals.


• Catalyst Stability: RuPhos enhances catalyst longevity and prevents degradation, delivering higher yields even under demanding conditions with superior stability and solubility.


• Versatility: Performs excellently across diverse solvents, temperatures, and reaction environments. Ideal forvaried applications, including Negishi cross-couplings of hindered aryl halides.


• Cross-Coupling Reactions: RuPhos enablesefficient C-C, C-N, C-O, C-F, C-CF₃, and C-S bond formation with minimal by-products. Particularly effective with hindered substrates like cyclic secondary amines.


• Precatalyst Integration: Incorporated into stable precatalysts like RuPhos Pd G3, offering enhanced handling and improved storage stability.


• Enhanced Reaction Conditions: Facilitates milder, environmentally friendly reactions while maintaining high catalytic activity and selectivity.


• Scalability: Suited for both laboratory research and industrial manufacturing, ensuring reproducible results across different operational scales.


Recent Studies and Innovations:




Steric Hindrance Effects: The study indicates that amines with large steric hindrance or halides with electron-withdrawing groups significantly reduce activation energy barriers in RuPhos-catalyzed reactions, enhancing overall catalytic efficiency and substrate scope. (Jiaqi Tian et al., 2020)

Catalyst-Transfer Polymerization (CTP): RuPhos excels in Suzuki−Miyaura catalyst-transfer polymerization (CTP), enabling precise synthesis of conjugated polymers with controlled molecular weights and narrow polydispersity. The ligand effectively facilitates polymerization of both electron-rich (donor) and electron-deficient (acceptor) monomers. (JaehoLee et al., 2021)

ISOM8 is a trademark of Sigma-Aldrich Co. LLC

M-CLARITY is a trademark of Merck KGaA, Darmstadt, Germany