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About This Item
Empirical Formula (Hill Notation):
HCl
CAS Number:
Molecular Weight:
36.46
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352301
MDL number:
Product Name
Hydrogen chloride solution, 4.0 M in dioxane
InChI
1S/ClH/h1H
SMILES string
Cl
InChI key
VEXZGXHMUGYJMC-UHFFFAOYSA-N
form
liquid
concentration
3.80-4.40 M (by NaOH, titration)
4.0 M in dioxane
density
1.05 g/mL at 25 °C
Quality Level
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Application
Hydrogen chloride solution (4.0 M in dioxane) can be used as:
- A reagent for the deprotection of the N-Boc protecting group from various heterocyclic derivatives.
- A reagent for the deprotection of polymer protecting groups. For instance, deprotection of benzyl ether-protected polymer.
- A polymerization initiator in combination with ZnCl2 in the synthesis of formyl terminated poly(ethyl vinyl ether) from ethyl vinyl ether (EVE).
General description
Hydrogen chloride solution contains 4.0 M hydrogen chloride in 1,4-dioxane as the solvent. It is commonly used as a deprotection reagent during the deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides. Additionally, it serves as a reagent in various organic synthesis reactions, including the synthesis of N-9-Fluorenylmethoxycarbonyl- (Fmoc) amino-acid chlorides.
signalword
Danger
Hazard Classifications
Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
supp_hazards
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
62.6 °F - closed cup
flash_point_c
17 °C - closed cup
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Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group using HCl/dioxane (4 m)
G H, et al.
The Journal of Peptide Research, 4, 338-341 (2001)
Preparation of N-9-fluorenylmethoxycarbonylamino acid chlorides from mixed anhydrides by the action of hydrogen chloride 1
FRANCIS C MF, et al.
International Journal of Peptide and Protein Research, 38, 97-102 (1991)
Surface-and redox-active multifunctional polyphenol-derived poly (ionic liquid) s: controlled synthesis and characterization
Patil N, et al.
Macromolecules, 49(20), 7676-7691 (2016)
Yun He et al.
Bioorganic & medicinal chemistry letters, 13(19), 3253-3256 (2003-09-03)
A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent
Synthesis of Chitosan-graft-Poly (vinyl ether) as a Thermoresponsive Water-Soluble Chitosan
Namikoshi T, et al.
Journal of Fiber Science and Technology, 75(12), 193-199 (2019)
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