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Merck

455180

Hydrogen chloride solution

2.0 M in diethyl ether

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About This Item

Empirical Formula (Hill Notation):
HCl
CAS Number:
7647-01-0
Molecular Weight:
36.46
NACRES:
NA.21
PubChem Substance ID:
329756805
UNSPSC Code:
12352301
MDL number:
MFCD00011324

Product Name

Hydrogen chloride solution, 2.0 M in diethyl ether

InChI

1S/ClH/h1H

SMILES string

Cl

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

form

liquid

concentration

1.90-2.20 M (with NaOH, titration)
2.0 M in diethyl ether

bp

34.6 °C

density

0.747 g/mL at 25 °C

storage temp.

2-8°C

Quality Level

100

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Application

Hydrogen chloride solution can be used as a reagent to synthesize:
  • Cyanohydrin alkyl ethers via chiral Bronsted acid-mediated hydrocyanation of vinyl ethers with silyl cyanides.
  • N, N-Dimethylaniline hydrochloride salts via Pd-catalyzed Buchwald-Hartwig amination of aryl triflates with dimethylamines.
It can also be used as a catalyst for the amidation of carboxylic acids with amines to synthesize amides.

General description

Hydrogen chloride solution contains 2M hydrogen chloride in diethyl ether as the solvent. It is a strong acid and highly corrosive in nature and is commonly used in the selective cleavage of the protecting groups 2,4,6-trimethoxyphenyl from the respective (2,4,6-trimethoxyphenyl)silane to produce chlorosilanes.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 1 - Met. Corr. 1 - STOT SE 3

target_organs

Central nervous system

supp_hazards

EUH019,EUH066

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-29.2 °F - closed cup

flash_point_c

-34 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4006
BCCN3472
BCCM1555
SHBR5667
SHBS0728

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Corrosion behavior of mild steel in hydrochloric acid solutions
Ehteram N A, et al.
International Journal of Electrochemical Science, 806-818 (2008)
An automated SPE-based high-yield synthesis of [11C] acetate and [11C] palmitate: no liquid-liquid extraction, solvent evaporation or distillation required.
Mock BH, et al.
Nuclear Medicine and Biology, 38(8), 1135-1142 (2011)
The 2, 4, 6-trimethoxyphenyl unit as a unique protecting group for silicon in synthesis and the silylation potential of (2, 4, 6-trimethoxyphenyl) silanes
Friedrich P, et al.
Organometallics, 26, 6014-6028 (2007)
Jay G Hosking et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(4), 1005-1015 (2014-10-21)
Successful decision making often requires weighing a given option's costs against its associated benefits, an ability that appears perturbed in virtually every severe mental illness. Animal models of such cost/benefit decision making overwhelmingly implicate mesolimbic dopamine in our willingness to
Ann Brinkmalm et al.
Molecular neurodegeneration, 9, 53-53 (2014-11-25)
Synaptic degeneration is an early pathogenic event in Alzheimer's disease, associated with cognitive impairment and disease progression. Cerebrospinal fluid biomarkers reflecting synaptic integrity would be highly valuable tools to monitor synaptic degeneration directly in patients. We previously showed that synaptic
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