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Merck

24368C

EX-CELL® Advanced CHO Feed 1 (without glucose)

Synonym(s):

EX-CELL® Advanced CHO Feed 1

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About This Item

NACRES:
NA.71
UNSPSC Code:
12352200

product line

EX-CELL®

form

dry powder

technique(s)

cell culture | mammalian: suitable (suspension)

shipped in

ambient

storage temp.

2-8°C

Quality Level

500

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General description

EX-CELL® Advanced CHO Feed 1 (without glucose) is chemically-defined and contains no animal derived components. This feed is intended to be a part of a fed-batch platform, and used with EX-CELL® Advanced CHO Fed-batch Medium (14366C or 24366C). This newest platform from SAFC has been specifically developed to support growth and productivity across a diverse set of Chinese Hamster Ovary (CHO) cells in fed-batch cultures while still allowing for flexibility in the adjustment of protein quality attributes. This contemporary fed-batch platform was developed using a strategy of Multivariate Analysis to establish correlations in which the formulation components influence critical process and product attributes such as titer, fold expansion, receptor expression, and glycosylation. This platform contains no hypoxanthine and thymidine, L-glutamine, phenol red or 2-mercaptoethanol (2-ME).

Other Notes

Submit the EX-CELL Advanced CHO Fed-batch request form to get in touch with a SAFC representative.

Preparation Note

Formulated to contain 34.1 grams of powder per liter of medium.

Legal Information

EX-CELL is a registered trademark of Merck KGaA, Darmstadt, Germany

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CorrosionExclamation mark
GHS05,GHS07

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Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
25E419
25E419
0000477019
0000477018
0000477018

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Pao-Chun Lin et al.
mAbs, 11(5), 965-976 (2019-05-03)
Chinese hamster ovary (CHO) cells are the biopharmaceutical industry's primary means of manufacturing therapeutic proteins, including monoclonal antibodies. The major challenge in cell line development for the production of recombinant biopharmaceuticals lies in generating and isolating rare high-producing stable clones

Articles

EX-CELL® Advanced™ CHO Fed-Batch System – Bioprocessing Technology Institute, Singapore Case Study

In this study, nine commercially available, chemically defined media and feed combinations from different vendors were assessed for producing monoclonal antibody in Chinese hamster ovary (CHO) cells.

Improving Fed-batch Yields in Upstream Bioprocessing

Our step-by-step guide to optimizing media and feed combinations for upstream bioprocessing.

Low-Impurity Iron Sources: Case Studies in EX-CELL® Advanced Medium

Discover how low-impurity iron sources improve reliability and performance in recombinant protein production with EX-CELL® Advanced medium.

One-step Feed Optimization for Upstream Cell Culture Processes

Optimizing feed for upstream cell culture improves monoclonal antibody production, but requires balancing outcomes for both viable cell density and productivity.

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