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Merck

91893

Poly(ethylene glycol)

greener alternative

BioUltra, 400

Synonym(s):

Polyethylene glycol, PEG

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About This Item

Linear Formula:
H(OCH2CH2)nOH
CAS Number:
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352104
MDL number:

Product Name

Poly(ethylene glycol), BioUltra, 400

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

SMILES string

C(CO)O

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

product line

BioUltra

form

liquid

mol wt

Mr 380-420

Quality Level

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.

sustainability

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impurities

insoluble matter:, passes filter test
≤0.02% peroxides (as H2O2):

refractive index

n20/D 1.467

pH

5.5-7.0 (25 °C, 50 mg/mL in H2O)

solubility

H2O: 50 mg/mL at 25 °C, clear, colorless

density

1.126 g/mL at 20 °C

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤300 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

50 mg/mL in H2O

UV absorption

λ: 260 nm Amax: 0.06
λ: 280 nm Amax: 0.03

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Application

Poly(ethylene glycol) (PEG) has been used to dissolve JC-124, nucleotide-binding domain, leucine rich family pyrin containing 3 gene (NLRP3) inflammasome inhibitor and solubilize CoQ10, a mitochondrial coenzyme Q4.

General description

Poly(ethylene glycol) (PEG) is a non-ionic hydrophilic polymer and is available in different molecular weights. It facilitates the purification and crystal growth of proteins and nucleic acids. PEG and dextran together result in aqueous polymer two phase system, which is required for the purification of biological materials. PEG also interacts with cell membrane, thereby allowing cell fusion.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Polyethylene glycol (PEG) is an eco-friendly, biodegradable polymer widely used in pharmaceuticals and cosmetics. Its non-toxic nature and versatility make it a sustainable choice, derived from renewable resources, contributing to greener product formulations. Click here for more information.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


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Poly(Ethylene Glycol) Chemistry: Biotechnical and Biomedical Applications (2013)
NLRP3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of Alzheimer?s disease
Yin J, et al.
Molecular Neurobiology, 55(3), 1977-1987 (2018)
Wenhai Sui et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(22), 10937-10942 (2019-05-16)
Mirabegron (Myrbetriq) is a β3-adrenoreceptor agonist approved for treating overactive bladder syndrome in human patients. This drug can activate brown adipose tissue (BAT) in adult humans and rodents through the β3-adrenoreceptor-mediated sympathetic activation. However, the effect of the mirabegron, approved
Woori Jo et al.
International journal of molecular sciences, 21(18) (2020-09-25)
The incidence of myocardial infarction, among the causes of cardiovascular morbidity and mortality, is increasing globally. In this study, left ventricular (LV) dysfunction, including LV systolic and diastolic function, was investigated in a rat myocardial ischemia/reperfusion injury model with echocardiography.
Idebenone and coenzyme Q10 are novel PPAR alpha gamma ligands, with potential for treatment of fatty liver diseases
Tiefenbach J, et al.
Disease models & mechanisms, 11(9), dmm034801-dmm034801 (2018)

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