A2559
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide
≥97% (HPLC), powder
Synonym(s):
Ac-DEVD-pNA
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About This Item
Empirical Formula (Hill Notation):
C26H34N6O13
CAS Number:
Molecular Weight:
638.58
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
assay
≥97% (HPLC)
form
powder
color
white
storage temp.
−20°C
SMILES string
CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc(cc1)[N+]([O-])=O
InChI
1S/C26H34N6O13/c1-12(2)22(26(43)30-18(11-21(38)39)24(41)28-14-4-6-15(7-5-14)32(44)45)31-23(40)16(8-9-19(34)35)29-25(42)17(10-20(36)37)27-13(3)33/h4-7,12,16-18,22H,8-11H2,1-3H3,(H,27,33)(H,28,41)(H,29,42)(H,30,43)(H,31,40)(H,34,35)(H,36,37)(H,38,39)/t16-,17-,18-,22-/m0/s1
InChI key
GGXRLUDNGFFUKI-ORGXJRBJSA-N
Gene Information
human ... CASP3(836)
Application
N-Acetyl-Asp-Glu-Val-Asp p-nitroanilide has been used as a chromogenic substrates for determining caspase-3 and caspase-8 activities in liver tissue homogenates and caspase 3 activity in aortic vascular smooth muscle cells and neuroblastoma cell lines.
Biochem/physiol Actions
Colorimetric substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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In vitro cell culture monitoring can be used as an indicator of cellular oxidative stress for the assessment of different chemotherapy agents. A cell-based bioelectric biosensor was used to detect alterations in superoxide levels in the culture medium of HeLa
Ouyang Chen et al.
Scientific reports, 7(1), 14871-14871 (2017-11-03)
The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH). C57BL/6 mice were randomly divided into the following groups: sham, I/R, I/R + HCH, I/R + HCH + LY294002 (PI3K inhibitor), I/R + HCH + wortmannin (PI3K inhibitor), I/R + LY294002, and I/R + wortmannin. After 45 min of ischemia, HCH