A3509
2-Aminopurine
≥99%, synthetic, powder
Synonym(s):
2-AP
Sign In to View Organizational & Contract Pricing.
Select a Size
All Photos(5)
About This Item
Empirical Formula (Hill Notation):
C5H5N5
CAS Number:
Molecular Weight:
135.13
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
207-197-4
MDL number:
Product Name
2-Aminopurine, ≥99%
InChI
1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10)
InChI key
MWBWWFOAEOYUST-UHFFFAOYSA-N
SMILES string
Nc1ncc2[nH]cnc2n1
biological source
synthetic
assay
≥99%
form
powder
mp
280-282 °C (lit.)
storage temp.
2-8°C
Quality Level
Looking for similar products? Visit Product Comparison Guide
Application
2-Aminopurine (2-AP) is used to specifically inhibit double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
2-Aminopurine has been used to inhibit eukaryotic initiation factor-2α (eIF2α)-phosphorylation of osteoarthritis (OA) chondrocytes.
Biochem/physiol Actions
2-Aminopurine (2AP) is an analog of guanosine and adenosine, which can base pair with cytosine and thymine. It is used as a fluorescent probe in nucleic acid structure and dynamics. 2-Aminopurine (2-AP) inhibits double-stranded RNA-dependent protein kinase, protein kinase R (PKR).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Julien Godet et al.
Nucleic acids research, 41(9), 5036-5048 (2013-03-21)
The HIV-1 nucleocapsid protein (NCp7) is a nucleic acid chaperone required during reverse transcription. During the first strand transfer, NCp7 is thought to destabilize cTAR, the (-)DNA copy of the TAR RNA hairpin, and subsequently direct the TAR/cTAR annealing through
2-Aminopurine.
A Ronen
Mutation research, 75(1), 1-47 (1980-01-01)
Endoplasmic reticulum stress induces the expression of COX-2 through activation of eIF2alpha, p38-MAPK and NF-kappaB in advanced glycation end products stimulated human chondrocytes
Rasheed Z and HaqqiTM
Biochimica et Biophysica Acta - Molecular Cell Research, 1823(12), 2179-2189 (2012)
Bakhos A Tannous et al.
Journal of the National Cancer Institute, 105(17), 1322-1331 (2013-08-14)
Glioblastomas exhibit a high level of chemotherapeutic resistance, including to the antimitotic agents vincristine and taxol. During the mitotic agent-induced arrest, glioblastoma cells are able to perform damage-control and self-repair to continue proliferation. Monopolar spindle 1 (MPS1/TTK) is a checkpoint
Double-Stranded RNA-Dependent Protein Kinase Is Involved in 2-Methoxyestradiol?Mediated Cell Death of Osteosarcoma Cells
Shogren KL, et al.
Journal of Bone and Mineral Research, 22(1), 29-36 (2007)
Related Content
Product Information Sheet
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service