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Merck

A5862

Anisomycin

Ready Made Solution from Streptomyces griseolus, 10 mg/mL in DMSO

Synonym(s):

(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate, Flagecidin

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About This Item

Empirical Formula (Hill Notation):
C14H19NO4
CAS Number:
Molecular Weight:
265.30
MDL number:
UNSPSC Code:
51102829
EC Number:
200-664-3
NACRES:
NA.85

Product Name

Anisomycin, Ready Made Solution from Streptomyces griseolus, 10 mg/mL in DMSO

SMILES string

N1[C@H]([C@H]([C@@H](C1)O)OC(=O)C)Cc2ccc(cc2)OC

InChI key

YKJYKKNCCRKFSL-BFHYXJOUSA-N

InChI

1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m0/s1

Quality Level

form

liquid
ready-to-use solution

concentration

10 mg/mL in DMSO

antibiotic activity spectrum

Gram-negative bacteria

mode of action

protein synthesis | inhibits

shipped in

dry ice

storage temp.

−20°C

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup


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K L Shires et al.
Nature communications, 3, 1246-1246 (2012-12-06)
In isolated hippocampal slices, decaying long-term potentiation can be stabilized and converted to late long-term potentiation lasting many hours, by prior or subsequent strong high-frequency tetanization of an independent input to a common population of neurons-a phenomenon known as 'synaptic
Einar Ö Einarsson et al.
Learning & memory (Cold Spring Harbor, N.Y.), 19(10), 449-452 (2012-09-18)
It has been suggested that memories become more stable and less susceptible to the disruption of reconsolidation over weeks after learning. Here, we test this by targeting the anterior cingulate cortex (ACC) and test its involvement in the formation, consolidation
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Molecular brain, 6, 17-17 (2013-04-17)
Fear is one of the most potent emotional experiences and is an adaptive component of response to potentially threatening stimuli. Cumulative evidence suggests that the amygdala plays a central role in the acquisition, storage and expression of fear memory. We
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The Type B trichothecene deoxynivalenol (DON), a ribotoxic mycotoxin known to contaminate cereal-based foods, induces ribosomal RNA (rRNA) cleavage in the macrophage via p38-directed activation of caspases. Here we employed the RAW 264.7 murine macrophage model to test the hypothesis
Stéphane Delmas et al.
Molecular microbiology, 87(1), 168-179 (2012-11-14)
In prokaryotes the genome is organized in a dynamic structure called the nucleoid, which is embedded in the cytoplasm. We show here that in the archaeon Haloferax volcanii, compaction and reorganization of the nucleoid is induced by stresses that damage

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