A8937

Adenosine 5′-triphosphate dipotassium salt hydrate

Name: Adenosine 5′-triphosphate dipotassium salt hydrate
Brand: SIGMA

≥92% (HPLC), microbial, powder

Synonym(s):

ATP, 5′-ATP-K₂

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All Photos(3)

About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄K₂N₅O₁₃P₃ · xH₂O

CAS Number:

42373-41-1

Molecular Weight:

583.36 (anhydrous basis)

MDL number:

MFCD00084672

UNSPSC Code:

41106305

eCl@ss:

32160414

PubChem Substance ID:

24891383

NACRES:

NA.51

Product Name

Adenosine 5′-triphosphate dipotassium salt hydrate, from microbial, ≥92% (HPLC)

InChI key

YFPSRAQDZYNYPX-IDIVVRGQSA-L

InChI

1S/C10H16N5O13P3.2K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

SMILES string

[K+].[K+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

biological source

microbial

assay

≥92% (HPLC)

form

powder

solubility

H₂O: 50 mg/mL

storage temp.

−20°C

Quality Level

200

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Related Categories

Biochemicals

Nucleosides and Nucleotides

Phosphates

Application

Adenosine 5′-triphosphate dipotassium salt hydrate has been used:

in in vitro transcription reaction as nucleotide source and in 2x RNA binding buffer
as a component of energy solution for calibrating crude cell extract
to test its dependency with PK11195 in mediating autophagy

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. Metabolic disorders lead to ATP deficiency. Use of xanthine oxidoreductase inhibitors and inosine improves intracellular ATP levels.

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems.

Disclaimer

For maximum stability, store as frozen solution at pH 3.5 to 6.8.

General description

Adenosine 5′-triphosphate (ATP) is synthesized in mitochondria by oxidative phosphorylation.

ppe

dust mask type N95 (US), Eyeshields, Gloves

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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RNA-protein UV-crosslinking Assay

Poria DK and Ray PS

Bio-protocol, 7(6), e2193-e2193 (2017)

Ca2+-dependent autophagy is enhanced by the pharmacological agent PK11195

Gastaldello A, et al.

Autophagy, 6(5), 607-613 (2010)

ATP synthesis and storage

Bonora M, et al.

Purinergic Signaling, 8, 343-357 (2012)

Protocols for implementing an Escherichia coli based TX-TL cell-free expression system for synthetic biology

Sun ZZ, et al.

Journal of Visualized Experiments, 7(79), e50762-e50762 (2013)

Shortage of Cellular ATP as a Cause of Diseases and Strategies to Enhance ATP

Johnson TA, et al.

Frontiers in Pharmacology, 10, 98-98 (2019)

View All Related Papers